Amgen Inc. v. F. Hoffmann-LaRoche LTD et al

Filing 582

DECLARATION of Adam Arthur Bier in Support of Opposition to Defendants' Motion for Summary Judgment that the Asserted Claims of the '933 Patent are Invalid for Indefiniteness and Lack of Written Description by Amgen Inc.. (Attachments: #1 Exhibit 1-Part 1#2 Exhibit 1-Part 2#3 Exhibit 2#4 Exhibit 3)(Rich, Patricia)

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Amgen Inc. v. F. Hoffmann-LaRoche LTD et al Doc. 582 Att. 4 Case 1:05-cv-12237-WGY Document 582-5 Filed 06/29/2007 Page 1 of 6 3 TIBIHXE Dockets.Justia.com 48019900 CTI-MA 714602076MA 194820 76 MA !aUnedifnoC .Cq'L .SqLL.Y�LIW �1 �mp r� evah �4r fo � � � re� .s� � r�sm ih ylno �ef� op�r r�sp uhc nI.lemp �.0 � �e namuh m �snu � e� fo gm 92.0 demfed � y�iv�ca opefo �n�n� enO" l�nem�xe .�.0 �w ya� � rof uneic -� no�tl�m no�au� nois� e� .selpmas e�fo �m� eteled m � �w noi� )elp�s r� se�ilp� � .Uew n� �n�e� �no�a�ofn� elbab�p d� �o�i�moc et�yh�c ni ecn�effid tae .raps � �ni �ad �no�da mes�p osla eW .e�i � no�v� m d� ,no�a�i fo e�e oz #�r d� )s �of � e�( �u nee� et�med ew r� tneserp e� nI .�o�p � e� neew� ni �n�e� �bo e� rof si�b laru� .c�s elbiss� y� ro �e fo �ffe �c�oloib eht rof �s e� z�ecnoc Ley nwo� si elttil �a� y� ot re�d �on od �ah� s�u� edecca,nilo h� eca�h�uc fo tnuoma yl�i�nesse evah o� denop� n� evah .�neu�s dica onima emas eht evah h�ob yeh� hguo� .�0�.031 tu�at �e-r seod na� �000.09 Pnie�mp fo 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fo etar � ci�c� �cric d� evitsv�ed dno -� .noita�i yb noitavitcani �oitanidoi fo me � t�ps� ht� reffid niteioporh�e �m "I'CARTS�A -uh tnanibmocer dn� �nirU "rNuwdloG eueguF duL� snuK .H..K ac|rahC sniteioP0rhtyrE yranirU dna tnanibmoceR neewteB ecnereffiD lanoitamofnoC elbaborP A Case 1:05-cv-12237-WGY Document 582-5 Filed 06/29/2007 Page 2 of 6 58019900 CTI-MA 814602076MA 294820 laitnedifnoMA C eno ta ytivitca .fo ssol on ro el�il setacidni evruc noit -avitcani eht ope-r rof tub ,ytivitca 'fo ssol etelpmoc owt esuac ot tne�s si el'lcelom ope-u rep smota ot eno fo nbrutUsbus .)2 .giF( uses �b nu �A .op4u si naht tne,-xe ressel yldekram a ot d�avitcsni si ope-r :no,snhcoi yb d,�r-� ylla/tner ,lfJd osla uw ,sis -ehtar.� nibolgomeh llec worram yb ortiv ni deruuem sa ,eno�reraperp ope owt *ht fo ytivitc� lxcigoio|B .�sni�oryt �ut suoit/dnoc se�ht rednu d�anidoi era taht ope ni seudiser ylno eht taht dnuof evah eW .ope.r rof n�ht ope-u rof rewol yltnacif/ugis si seudsser elbatanidoifo 7t�bissocea eht taht �seggus pmdnlf esehT .elucelom ope rep I "fo smota 4 naht erom erew ereht ,o/tar ope/laN emas eht ta ope-r rof tub .8 saw erutz/m noitcaer eht ni ope/laN.fo oder ralom eht nehw ope'fo elucelom rep l.fo smota 2 naht ssel saw noitut/tsbus ,ope-u htiW .ope-u dna ope-r neewteb no/tanidoi .fo esae ni ecnereffid dekram � wohs aralc ehT .denimreted noitutitsbus enidoi fo tnuoma eht dna deirav saw erutzim noitcaer eht n, mLar ralom ope/I�";aN eht hrJhw ni tnem -irepxe na morf devired erew 1 eruriF ni erad ehT 76 STLUSER .nekram thgiew ralucelom eht erew sa .,AC .selucreHC deroiB m�h thguob erew EGAP -SDS rof seilppuS .miehnnaM reznirheoB morf �ot ,bihni nispyrt naebyos dna no�nihtroW morf nssp�t KCPT .slacimehC �maiS morf 0461 IMPR dna .esanacylg.O ,esanzcylz-N .e�Lcit�is .}�L�I .not -EmmliWt reviR selrahC morf star snavEpno I .�RA .rezoR lac�oloiB ezeerF.laP morf mures tar dna .)'/�1 .dnalsI dn�tG( LRB/OCBIG morf 901 CT'CN dna .secuhim 03 rof C"65 ta de.�aeh saw hcihw ,mures tJeef .}LI .sthgieH no�nilrA( .proC �aheremA morf enidimyht.l-q dna .In�aN ,)lCeFn .lLI .drof .kcoR( ]aclmehC ecreiP m�if thguob uw negodoI .selpanas cse� eht sa leg eht no nur �row )4030-161 .on .tac( sdradna�s thgi�w �lucelom EGAP-SDS pnar wol daR-oiB .yleu�uoR Lceilppa uw mc/V 02-5� .fo tneid�'�g paw lov tnatsnoc A .)ozI mc 8 x )�( mc 7 x mm 5,0 st s ezis lp ehT ea Llmme�L'fo metsys reyub suo�nit -nocsid eht ni dna )ed/malyrcaylop �5.4,1eZ �reppu, znikcars � dna ,edimalyrsaylop E'51( lez �rewol� gni -tarapes � .fo zn�tslanoc le� ed/malyrcaylop suounit .nocsilc � ni nur dna dedaol eraw'elpmas derutaned eht �o llew rep |l�'�m 05( dl 4-1 erutarepmot moor ot |n/looc ret/A .]eulb lonehp,,,orb lv/w{ �c5T30.0 .lonahtempacrem.B )v/v, Eq5 .lorecyl� �v/v� �0I .�.6 Hp sirT M 5260.0 ,SDS }v/wt �.2[ reyub elpmas se�unim � rof C0001 t� znitaeh yb derutaned erew )ll�n 00�51 selpmas nietorp ehT �t .ilmmeaL ot fnidrocca enod s�w siserobportcele leG .ope-u rof lm/U 5.� dna ope-r rof lm/U 9.4 erew se�r�vi�ca em�t orez ehT .yassa rof detulid roht �uf neht erew selpmas ehT .ASB �C1.0 gniniatnoc SBP dloc.fo lm 0.1 yb dewollof ,02 neewT �e20.0 sulp 5.6 Hp reffub etahpsohp M 1.0 ni tmFn 2t rotibihni nispTrt naebyos.fo noitulos �'to I;5 oc dedda ,setunim dna .3 .I ta devomer erew llu21 �touqilA .C"73 dotarbil�uqeerp slaiv ot dedda 8 Hp 02 neewT ET0.0 sulp =ICaC � 10.0 .reyub siri" Ib 1.0 ni nisp/-rc KCPT "fo noitulos ]mWn 1.1 a "ro i�6 dna devomer erew )lt�2( uouqila emit oreZ .laiv.V detaoc-GEP a ot dedda erew 2.7 Hp reffub etahpsohp Mm 2 ni )ope-u dna .r htob rof 452.0 o�At �pe'/o I�02 :swol .io.f sa enod erew stnemirepxe sisylordyh nis�T .stius -er emas eht yllaitnesse htiw sesylana ruot fo eno tneserper 3 erugiF ni a=ceps ehT .572.0 saw ope-u ro.f dna 172.0 saw epe-r rof o�A ehT .reffub emas eht dna se�tevuc htap thgil mc-1 desu ew mn 023-052 �nar htgnelevaw eht roF .T61.0 saw ope-- rof dna 561.0 saw ope.r tot o�zA ehT .T I-Ip ta etahpsohp M.m ni ope htiw htap thgil mc.l.0 htiw setcevuc desu ew .ma 052-091 noiger h,'gneleva-,v eht roF .006.3 ledom ocsaJ a no enod erew artceps DC 'srekrowoc dna enogaR "fo dohtem eht yb dezylana artceps evitavired dnoces eht dna ,erawtfos gnitarepo nacs decnahne znisu yb tnemurtsni 34 adbmaL remlE .nikreP � ht�w demro'trep saw ypocsortcepS '.kcepS dna rekarF.fo dohtem eht yb enod saw noitanidoI .dnalkcirtS dna laL yb debircsed dohtem eht yb deif -irup saw h .enog ope namuh deifilpma na zniyrrac sliec 7mvo retsmah esenihC mo ,if devired uw dna .cnI hsimA ,,,orf �g a saw epe-r e�T .UA/U 007,88 fo ytivitca cificeps a evah ot deyassa saw noitar .sperp emas eht .enod erew stnemirepxe ,eseht ne�K '.deifirup �srif saw ti nehw UA/U 007.28 "ro ytivitca cificeps lan:gno s�i deniater dah hci�w ,deraperp yllanigiro taht �sw stnemirepxe eseht m desu ope-u eht lairetam gnitrats 'fo yticracs eht .fo esuaceB 59 LACI'I'%..FD| TOY � S�'Lr-LIOPORH'�'RE.'..T D'%.A -R Case 1:05-cv-12237-WGY Document 582-5 Filed 06/29/2007 Page 3 of 6 68019900 CTI-MA 914602076MA 394820 76 MA laitnedifnoC s�n�e��o fo e�-� e� �n� tes re�o� yB a .etu� 1 tu�a fo .�oit wohs )4 t d� �elc �ev -re� �I �ev .ziF( yb ulus� e� nouav�8� �o�o� elbis� a e�s� e�Fo � Fo ts� ce�o� � �no�ne u�gus � �2�82 d� ton si le� SDS �nicuder ,znnucaned = no snietorp rekram rof tolp ecnatsid sv ,�I 8oI eht esuaceB .smrof owt eht neewteb ycnetop ni ecnere�d eht rof sisab eht �ou ylraelc saw lonehp ot eruso�ze ,)no3racinummoc lanosrep .e�E .J dna dnadlcirtS .Tf dot��t os con epe-r seod u ycnetop emas eht sah op4u rof desu dohtem emas eht v.b deifirup dna lonehp htiw dota�= ylral -imis op4r ecniS .ytivitca rewol htiw no/t�mrofnoc tnereEUc tahwemos � ot dedlo'f�r ,noitulos suoeuqa ot donruter gnieb retfa .dna dedlofnu neeb evah yam ti nehw dohtem noitac�rup !�iro eht ni lonehp ot ope-u fo erusopxe eht ot eud neeb evah thS�m devres -bo ew JsenereCLlc eht taht elbisuzlp demees tI a =�us � 0�91 �dn� � ecnereffid no� e� � �n�e�d -ffub tnereSid ni denimreted erew detroper artceps DC eht ,noiciLcda nI .dohtem siht yb op4r dna -u "ro nosirapmoc leer/d � ereht SLw repap rehtien ni tub artceps DC ralimiS .�3 .giF( �t'n ,dehsilbup neeb evah atad cipocso'nceps ciorhcUc rslucr�c eht ht=w �nem .eer�a ni .op�r dna op�u neewteb erutcurts redro reh�h ni ecnerefft.? 8 .sno/tsunecnoc tnzre'�id ta dna are v.b sisv.lerdv.h ot ")tilibitpecsus etseSZus osla )4 .ziFt niepTu laitnereffid ehT erom .epe-u ni elbissecca si tub .)I elbaT( �u � �4r n� �e� t�s �ub l�ms a s�hs tnevlos e� W �e saudi� e�s� � �n eht fo �am=� e� ,�o=� ese� m�F .)30L( e�s eht era �taned eht m op<u dna -r rof oit� � e�e =eu�v e� .seudiser eniso�t �no�ne e� � ecnere�d a gmt�e� �ob� � eht ni ecnere�id �eht wohs elbaT ni =�ad eht � .ypoc�s noi=�osba evusv�ed-dnoces fo yduts yb nev� si nob�etni �ht rof �puS .�a lac�oloib ni noi�a�ofnoc fo elor d� .ssudis� !�so�t !�m fo ��libissecca �o sned ta.eVid � �ser �ouaraperp �e e� fo no�o� ni �uereffid s �o ecnedi-�e �no�da � o� op�r ni deksam tahwemos si enieorvt lacic�c a ��lt tse||ue )� .giF( noitutitsbus emLcoi yb detavitcani ylisae erom hcum si ope-u taht szniLcm� ruO .snoil -ara�lerp ope owt eht neewteb artceps eri=tav/reit dnoces ni ecnereff/d eht ht�w se�3Za �1 .ziFt noi�a -nidoi ot ope-r ni senisor�r fo ytilibissecca retaer� ehT .ope-r dna -u rof setas lanoitamrofnoc tnereffid "fo evi�se�us ylrnorcs atad detneserp evah eW �s� ese� �er�etni � .elucelom Ttm�a orez ot setalopartxe ta ta NOISSUCSID dna ,ope/� oerht noitavitcani �.03 tuoba .o�e� .selp�/Ks � htob rof emas eht gnieb )aDk 6L2( eugav lanif eht htiw ,t� ni se�nahc lauqe desuac esanacv.lg.'h htiw tnenuaert elihw ,ope-u rof �O.k 0L dna ope-r ro'( aDk 9.2 "ro ssol ni detluser tnemtaert esanacv.IG.O .ope-u rof a�k 1.4 dna ope-r rof aDk 4.3 "fo ,M ni esaerced desuac esadilaiS .ope-u n.sht ,KI ni retaerg aDk �.1 OPE REP tuoba gnieb oge-r htiw ,selpmas ope-u dna -r evitan neewteb �I%. ni secnereff/d tnacif/�zis dnuof e;V .SDS fo ecneserp eht ni leg edimalTtcav.lop �51 .gnicuder a no denimreted 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G�.%� H-Li.� Case 1:05-cv-12237-WGY Document 582-5 Filed 06/29/2007 Page 4 of 6 78019900 CTI-MA 024602076MA 494�20 T6 MA dhtnedifnoC cifuyine oi oud secnere'�lc ehT .egnar eht fo dne hzih eht ta uw ti nus s�ht ni :000.83 dna 000.23 neewteb senav op4r rof rM tn�,Lppa eht sdn�h ruo nI .dohtem � v.b ,M.rof seulav tnetsisnoc dna e�cerp tel oc tlucS�d si ti ,noitisopmoc lez ni sefnzhc ,ope fo ezis op�o snoU .arlpirp anera'llid fo esuaceb i reiirie deinHerp esoht morf ie[ilc ylbaborp siad ruO :i-*l.sniiliys noos -serilxe rihto htiw snoitavresbo fo weiv ni yllaicepse .laer yrev si yllacitnedi nietorp ope eht walysocyl� ton od lipyi llec inirafid eht taht wlilbismp ehT n .ow't eht ileewceb eenerefilc on yllailnello dewohs .sllec OHC aiht rehtar ,sllec SOC yb do�ixe op4r dna -u fo yduts ralimis A .ilisiofpocyl| eht fo fnidlo� no noitisopmoc �zrlcv.hobrsc ni ,cnorerfw eht fo tco'tfe na ot eud eb yam noitam'zo�loc ni dnif ew secn�re�ifc ehT �-� .seulav d�rop�r rehto ht�w ni ope-r naht dica cilais �om dna ed�r ope-u �iw tnetnoc .ahcc�ilo dekn�-O ssel gnivah .leg emzs eht no derzpmoc nehw dica cilsis ni ylbissop dna ,csrlcyhobrac dekml -O ni ocnmeWlc � nezzus II elbaT ni a�ad ehT ope evitan ht�w dna rehto hcae htiw tnetsisnoc era ,revewoh ,si�lorLcv.h z�lucelom eht tuoba ta sdneb dna raenil .emyzne hcae hllw tnemtaert retfa illiqcw ralucelom tnerspila m ecnerefilI eh/m sref�r .MI. 3.01 0.1 1.4 �01 9.2 4.3 esmz:w.l[.�. essnz�l�-O o/s�sA evus�. dk 6.12 9.13 9.23 0.73 dk dk 6,12 9.13 8.43 2.83 dk dsxa tnanibmoceR'fo no �fb�ieW radtcelo[%, tm�.app.q'. etardyhobraC fo/3..om�P fo uce�.F LI ZL3AT .� 9.5 saw �u fo l� ona �/Um 8.3 A O42 �.2 042 )mn( t�gneevaW O32 022 012 0 )e� 06 O8 ,00I .O0O:2 79 LACITNEDI TO�. � S�L'�LIOPOHH'�'�E-�L D'�& oR Case 1:05-cv-12237-WGY Document 582-5 Filed 06/29/2007 Page 5 of 6 88019900 CTI-MA 124602076MA 594820 76 MA laitnedifnoC .T-�L ,pmi llec aimekuel namuh tn�tbm� �s�@ nutt�e �hfe ro s�u�tS .S.H .td�oC ..J sednahcca�gho �aty�s a dna tnemh�ibms[ .Y .aruiM ..S .TS91 .232�2�019 � ,�o,B .mth�iB �kntl.N rof ei� a �v �l�ab gm� � �i m �mp� nue�h�e �a �uh e� fo .mijuF ..M .�mamaY ..N .snaeroK 6 .4791 .�2024:94� d,�s �i/ms fo elor fo msm �,�e m �udm.nuei�m�e .�l� � d� ennu � e� fo �oloib .8�91.3663 re�ah e�em�C m�f deifirup nsmuh tna�m� � n�u� K .�S .� �bihC .�gl .�::2 sedn�gho �knh.N fo yats �s �u�moC .10i� .J �N� �el�e .7891 .67021�021:2�2 .mehC �uh � yb sliec �avo ,422 �w� .�T ,.G ..H �C � .�S .,� ..M .�'L .� � .� .�u� � .� .E �usT .4� .m� fo �e �o�ib d� nous�e�C �.D .seniH l�olmb d� .riaH gnnpS dloC L �P.15.loV m�S r� gnnpS dloC :nI m�p ,�mnod en� ,�u�ts ..K.F .n� ..H-P .� .-C.� .r�wdl� ,.T ,e� ..M�ehoC .�.J ,e�E .gnaw .� ct�E ..H.P .� .ou�C .0T91 .�6 � e� fo .31 .� .J .nues� �h ,.H-K.C �n�K ..T .ekayiM aw� ..F.F �muh tn�tbm� (o .,T -lTSl.� �on� fo yI�es� .oga�C fo ytis .revmU e� m .cnI �ez�-n� m� R� a yb dna exut�snl �IB d� .znuL .leE lanoitaN e� m�f yb �p ni �n�pus �w krow si� �GD�O�CA �t�n�sB .yp�s e�tavne� .�hpoeB .meh�B ,�ul�lyn�hp�,�oihc�et �.4.3.1 .eO�m�ol� �bul� y i�nn�s s �w �obanl�s en�bmem II� � a� rJ .C.J L�S ..JP .rex�F .8 ,7 .�ou�p�p o� eseht rof d�of y�sizca la:�oimb m �n�e� e� �f �a osla yam h ,sisyl�dyh d� seudiser emsov)� e�fo o� ro eno fo �nemnm�n� ra�elom � mtne -�ppa Y�a�se � �n�e�d � .�ei�orh�e d� �bm�r n� �cn�reffid lanoit -amrofnoc tnzcifi�n�is � �s�g�us ylgnorts atad ehT mtetop�rh�'�;� WT .dn�/kcmS ..H.P .�L NOISULCNOC Case 1:05-cv-12237-WGY Document 582-5 Filed 06/29/2007 Page 6 of 6

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