Amgen Inc. v. F. Hoffmann-LaRoche LTD et al

Filing 627

DECLARATION re #624 MOTION for Summary Judgment that Amgen is Estopped from Asserting Infringement Under the Doctrine of Equivalents of the Asserted Claims of the '698 and '868 Patents by Nicole A. Rizzo by F. Hoffmann-LaRoche LTD, Roche Diagnostics GmbH, Hoffmann LaRoche Inc.. (Attachments: #1 Exhibit 1, Part 1#2 Exhibit 1, Part 2#3 Exhibit 1, Part 3#4 Exhibit 1, Part 4#5 Exhibit 2, Part 1#6 Exhibit 2, Part 2#7 Exhibit 2, Part 3#8 Exhibit 2, Part 4#9 Exhibit 3#10 Exhibit 4#11 Exhibit 5#12 Exhibit 6#13 Exhibit 7#14 Exhibit 8#15 Exhibit 9#16 Exhibit 10#17 Exhibit 11#18 Exhibit 12#19 Exhibit 13#20 Exhibit 14#21 Exhibit 15)(Rizzo, Nicole)

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Filed 07/03/2007 Page 1 of 15 EXHIBIT 1, Part 2

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Case 1:05-cv-12237-WGY

Document 627-3

Filed 07/03/2007

Page 2 of 15

U.S. Patent

Aug. 15, 1995

Sheet 2 of 27

5,441,868

FI G. i
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Pst 1..\
ApR

016500

pDSVL- MkE

SV40ori...,

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, SV40 po1y.A signol

Case 1:05-cv-12237-WGY

Document 627-3

Filed 07/03/2007

Page 3 of 15

U.S. Patent

Aug. 15, 1995

Sheet 3 of 27

5,441,868

F/G.3
RI

J SV40crj

/

BamHI

H"""_n PSVgHuEPO ) I

\\i/
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\.".,... .' ,/ . "'", // ~--

Case 1:05-cv-12237-WGY

Document 627-3

Filed 07/03/2007

Page 4 of 15

U.S. Patent

Aug. 15. 1995

Sheet 4 of 2ï

5,441,868

FIG.

4
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GA TCCCGCGCCCCCTGGACAGCCGCCCTCTCCTCCAGGCCCGTGGGGCTGGCCCTGcee

Case 1:05-cv-12237-WGY

CGCTGAACTTCCCGGGATGlIGGACTCCCGGTGTGGTCACCGCGCGCCTAGGTCGCTGAG

-27

-20
-10

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Met Gly Val His Glu cys Pro Ala Trp GGACCCCGGCCAGGCGCGGAGnTG GGG GTG CAC GAA TOT CCT Gce TOG

~

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Document 627-3

l,ou Trp Lou Leu Leu Ser Leu Val Bel' Leu Pro Leu GlY Lou Pro eTG TGG CTT eTe eTG TCT eTe GTG TeG eTe CCT eTG GGe eTC ccn

-1 +1 10 Val Pro Gly Ala Pro Pro Arg Lou 110 eya Asp SOl' Arg Val Lou GTC eCG GßC Gce ccn CCA CGe eTe ATe TGT GAe AGC can GTC eTG

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~

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. 20 Giu Arg Tyr Lou Leu GIii Ala LY6 GIn AlA Glu Asn Val Thr Met GAG AGG TAC eTe TTG GAG Gee AAG GAG Gce GAG AAT GTe ACG ATG

Filed 07/03/2007

GGG TOT Tee OA1\ AGC TOC AGe TTO AAT GAG A1\T ATC Ace GTC con

. 30 (0 Gly eye Bor Glu Bor eye Bel' Lou AsU GIii Asn 110 Thr Val Pro

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Asp Thr LY~ Val Asn Pho Tyr Ala Trp Lys Arq Hot Giu Val Gly GAC Ace AhA aTT AAC TTC TAT Gce TGG AAG AGG ATG GAG GTe GGG

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Case 1:05-cv-12237-WGY

70 GIn GIn Ala Val Giu Val Trp GIn Gly Leu Ala Leu Lou Bor Glu CAG CAG GCT GTA GAA GTe TOG GAG GGe eTG Gce eTG CTe TeA G1'A

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. .. Ala Val Leu hrg Gly GIn Ala Val Leu Ala Asn Bor Ser GIn Pro
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GCT GTC eTG CGG GGe cr.G Gce GTG TTG Gce Me TCT Tee CAG ceT

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Fho Glu Pro Leu GIn Lou Uis Hot Asp Lyn Ala 110 Bor Gly Leu TTC GAG cee eTO CAG eTG CAe ATG GAT 1'A1\ Gce ATC ACT GGe CTT
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Document 627-3

11.
120

Arg nor lia Thr Thr Lou Lou Arg Ala Lou Gly Ala GIn Glu Ala CGe AGe ATC Ace ACT eTo CTT CGG GCG eTG Gar. Gce CAG GAA Gce

13.
140

~

'0

riD Bor Lou Pro Asp Ala Ala Bor Ala Ala Pro LoU Arg Thr ¡Ie ATe Tee eTO CCr. GAT GCG GCe TeG GCT GCT con eTe con Ace ATC

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Filed 07/03/2007

Thr Ala 1\9p Thr Pho oya Lys Leu Pha Arg Val Tyr Bar 1ian Pha ÄCT GeT GAC ACT TTC TGe AAA CTC TTC CGA GTe TAe Tee AAT TTC

1 ..:

Page 6 of 15

FIG.5C
150
160

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Leu Arg 01y 1,YS Leu Lys Leu Tyr Thr 01y GIU Ala eyo Arg Arc;
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eTC eGO GGh AAG eTG AAO eTa TAC ACG GGG GAG Gce TOC AGO AGA

Case 1:05-cv-12237-WGY

Gly lisp Arc; OP

GGG G~C AGA TOA CCAGGTGCGTCCAGCTGGGCACATCCACCACCTCCCTCACCAACA

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CTGCCTGTOCCAChCCCTCCCTCACCACTCCCGAACCCCATCGAGGGGCTCTCAGeTAAG

Yl
'C U,

~ ~ 'C

CGCCAGCCTGTCCCATGGACACTCCAGTGCCAGCAATGACATCTCAGGGGCCAGAGGnAe

TGTCCAGlIGCACAACTCTGAGATCTAAGGATGTCGCAGGGCCAACTTGAGGGCCClIGAGe

Document 627-3

AGGAAGCATTCAGAGAGCAGCTTTAAACTCAGGAGCAGAGACAATGCAGGGAAAACACaT

GAGCTCACTCGGCCACCTGCAAAATTTGATGCAGGACACGCTTTGGAGGCAATTTACCTG

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~

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TTTTTGCACCTACCATCAGGGACAGGA TGACTGGAGAACTTAGGTGGCAAGCTGTGACTT

a .~
.~

CTCAAGGCCTCACGGGCACTCCCTTGGTGGCAAGAGCCCCCTTGACACTGAGAGAATATT

rrTGCAATCTGCAGCÄGGA~ÄAA TTACGGACAGGTTTTGGAGGTTGGAGGGTACTTGACAG
U1

Filed 07/03/2007

GTGt GTGGGGAAGCAGGGCGGJAGGGGTGGAGCTGGGATGCGAGfGAGAACCGTGAAGAC

~GGA TGGGGGCTGGCCTCTGGTTCTCGTGGGGTCCAAGCTT

1=
Page 7 of 15

FtinA,III

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Case 1:05-cv-12237-WGY

~~GCTTCTGGGCTTCC~G~CCCÄGCTACTTTGCGGAACTC~GCAACCCAGGCATCTCTGAGTCTCCGCCCA

AGACCGGGATGCCCCCCAGGGGAGGTGTCCGGGAGCCCAGCCTTTCCCAGATAGCACGCTCCGCCAGTCCC

0l

~
yi

AAGGGTGCGCAACCGGCTGCACTCCCCTCCCGCGACCCAGGGCCCGGGAGCAGCCCCCATGACCCACACGC

-

ACGTCTGCAGCAGCCCCGCTCACGCCCCGGCGAGCCTCAACCCAGGCGTCCTGCCCCTGCTCTGACCCCGG

~ ~ ~ 0'

GTGGCCCCTACCCCTGGCGACCCCTCACGCACACAGCCTCTCCCCCACCCCCACCCGCGCACGCACACATG

CAGATAACAGCCCCGACCCCCGGCCAGAGCCGXAGAGTCCCTGGGCCACCCCGGCCGCTCGCCTGCCGCTG
on

Document 627-3

CGCCGCACCGCGCTGTCCTCCCGGAGCCGGACCGGGGCCACCGCGCCCXGCTCTGCTCCGACACCGCGCCC

'" ~ ~ ..

CTTGGACAGCCGCCCTCTCCTCTAGGCCCGTGGGGCTGGCCCTGCACCGCCGAGCTTCCCGGGATGAGGXX

Hot Gly Val His CCCGGTGACCGGCGCGCCCCAAGTCGCTGAGGGACCCCGGCCAAGCGCGGAG ATG GGG GTG CAe G

-27 -2.

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Filed 07/03/2007

GTGAGTACTCGCGGGCTGGGCGCTCCCGGCGGCCGGGTTCCTGTTTGAGCGGGGATTTAGCGCCCCGGCT

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Page 8 of 15

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l'G.6ß

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ATTGGCCAAGAGGTGGCTGGGTTCAÄGGACCGGCGACTTGTCAAGG~CCCCGGAAGGGGGAGGGGGOTGGG

= ..

GC~GCCTCCACGTGCCGCGGGGACTTGGGGGAGTTCTTGOGGATGGCAAAAACCTGGCCTGTTGAGGGGCA

Case 1:05-cv-12237-WGY

CAGTTTGGGGTTGGGGAGGAGGTTTGGGGTTCTGCTGTGCAGTTGTGTCGTTGTCAGTGTCTCG (r. B' 1

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TTGCACACGCACAGATCAAT AAGCCAGAGGCAGCACCTGAGTGCTTGCATGGTTGGGACAGGAAGGACGAG

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CTGGGGCAGAGACGT(lGGGATGAAGGAAGCTGTCCTTCCACAGCCACCCTTCTCCCCCCCCGCCTGACTCT

, ¡n

-23

-20

~ ~ ~ ~, u

CAGCCTGGCTATCTGTTCTAG

Glu cys Pro Ala Trp LoU Trp Leu Lou Lou 8ar Lou AA TGT CCT GCe TOG eTG TOG CTr eTC eTG Tee eTG

Document 627-3

-10
+1

-1

Lou Bar Lou Pro Lou Gly Lou Fro Val Lou Gly Ala Pro Pro Arg Lou 11e Cys eTG TOG eTC CCT eTG GGe eTC CCA GTC eTG GGe GCe CCA CCA CGO eTC ATC TGT

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10 20 A9p Bar Arg Val Leu GIU Arg Tyr Leu Lou Glu Ala Lys Glu Ala Glu Aan lIe GAe AGC CG~ GTe eTG G~G AGG TAC eTC TTG GAG Gce AAG GAG GCe GAG AAT ATC

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Thr

2.

Filed 07/03/2007

ACG GTGAGACCCCTTCCCCAGCACA TTCCACAGAACTCACGCTCAGGGeTTCAGGGAACTCCTCCCAGAT

CCAGGAACCTGGCACTTGGTTTGGGGTGGAGTTGGGAAGCTAGACACTGecCCCCTACATAAGAATAAGTC

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Page 9 of 15

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FIG.6C
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Thr Oly ers Ala Glu
ACG GGe TOT GCT GAA

TGGTGGCCCCAAACCA TACCTGAAACTAGGCAAGGAGCAAAGCCAOCAOATCCTACGCCTaTaaOCCAOGG

Case 1:05-cv-12237-WGY

27

30

CCA~~GCCTTCAGGGACCCTTGACTCCCCGGGCTGTGTGCATTTCAG

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His Cyn Bar Lou Asn Giu Asn 110 Thr Val Pro ASp Thr Lys Val 1190 Phe Tyr CAe TOC AGe TTG AhT GAG AAT ATC ACT GTC CCA GAC Ace AAA GTT hAT TTC TAT

~
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Document 627-3

50 55 Ala Trp Lyn Arg Met Giu GCe TGG AAG AGG ATG GAG GTGAGTTCCTTTTTTTTTTTTTTTCCTTTCTTTTGGAGAATCTCATT
~ m

'l'GCGAGCCTGA TTTTGG1\TGA1\AGGGl\G1i1\TG1\TCGGGOGA1\J\GGT1.\.AATGGAGC1iGCAGAGATGlIGGCT

:! ~
o ~

GCCTGGGCGCAGAGGCTCACGTCTATAA TCCC1\GGCTGAGATGGCCGAGATGGGAGAATTGCTTGAGCCCT

o

GGAGTTTCAGACCAACCTAGOCAGCA TAGTGl\GA TCCCCCATCTCTACAAACATTTA~AAAA TTAGTCAG

,~

"

GTGAl\GTGGTGCA TGGTGGTAGTCCCAGATATTTGGAAGGCTGAGGCGGGAGGATCGCTTGAGCCCAGGAA

'lTTGAGGCTGCAGTGAGCTGTGhTCACACCACTGCACTCCAGCCTCAGTGACAGAGTGAGGCCCTGTCTCA

Filed 07/03/2007

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Page 10 of 15

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FIG. 6D

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AÄAAAGAAAAGAAAAAAGAAA~A TAATGAGGGCTGTATGGAA TACATTCATTATTCATTCACTCACTCACT

C ACTCA TrCA TTCATTCATTChTTCAACAAGTCTTATTGCATACCTTCTGTTTGCTCAGCTTGGTGCTTGG

Case 1:05-cv-12237-WGY

GGCTGCTGAGGGGCAGGAGGGAGAGGGTGACATGGGTCAGCTCGACTCCCAGAGTCCACTCCCTGTAG

56 60 70 Val Gly GIn GIn Ala Val Giu Val Trp GIn Gly Leu Ala Lou Leu Bar Glu Ala GTC GGG CAG CAG Gce OTA GAA GTC TGG CAG GGe eTG Gce eTG eTa TeG GAA GCT

i' ;;

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8.
100

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.0

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Val Lou Arg Gly GIn Ala Lou Lou Val Ann Bor 8ar GIn Pro Trp Glu Pro Lou GTe eTG CGG GGO CAG Gce eTG TTG GTC AAC TOT Tee CAG ceG TGG GAG cce eTG
en

Document 627-3

Oln Lou His Val ASp Lys Ala Val Bor Gly Lou Arq Bar Lou Tbr Thr Lou Lou CAG eTG CAT GTG GAT AhA GCe GTC AOT GGe CTT cae AGe eTC Ace ACT eTG CTT

'~ " ~

~
o ~
N "

115 11. Arg Ala Lou Gly Ala GIn eGG GCT eTG GGA Gce CAG GTGAGTAGGAGCGGACACTTCTGCTTGCCCTTTCTGTAÄGAAGGGG~

GAAGGGTCTTGCTAAGGAGTAChGGAACTGTCCGTATTCCTTCCCTTTCTGTGGCACTGCAGCGACCTCCT

Filed 07/03/2007

116
Lytl G1u :114

110 80r Pro Pro Asp Ala 1\la Ser Ala

120

GTTTTCTCCTTGGCAG

hAG G1\1\ GCC JlTC TCC CCT CCA G1iT GCG Gec TeA GCT GCT

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FIG.6E
140

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Pro Leu ì\rg Thr 11e Thr 1ÜlI Asp Tlir Phe Arg Lys l.eu Phe Arq Val Tyr Ber
150 160

130

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Case 1:05-cv-12237-WGY

CCA eTe CGA ACA ATC ACT GeT GAC ACT TTC CGC AA eTC TTC CGA GTC TAC Tee

1\gn rho LotI Arg G1y Ly~ Lou LyS. Lou Tyr Thr Gly Glu Alii cys Arg Thr Gly

c

AAT TTC eTC eGG GGA nAG eTG AhG eTG TAC ACA GGG GAG Gce TOC AGG ACA GGG

166

~ y.

ASp Arg OF GhC AGh TGA CCAGGTGTGTCCACCTGGOCATATCCACCACCTCCCTCACCAACATTGCTTGTGCeACA

~ ~

UI

Document 627-3

CCCTCCCCCGCCACTCCTGAACCCCGTCGAGGOGCTCTCAGCTCAGCGCCAGCCTGTCCCATGGACACTCC

A~TGCCAGCAJ\TGACA TCTCAGGGGCCAGAGGAACTGTCCAGAGAGCAACTCTGAGATCTAAGGATGTCAC

'~ "

AGGGCCAACTTGAAGGGCCCAGAGCAGGAAGCATTCAGAGAGCAGCTTTAAACTCAGGGACAGAGCCATGC

. a l~

TGGGAAGACGCCTGAGCTCACTCGGCACCCTGCAATTTGATGCCAGGACACGCTTTGGAGGCGATTTAC

o ~

CTGTTTTCGC~CCT~CC~ TC~GGGhCAGGhTGACCTGGAGAACTTAGGTGGCAAGCTGTGACTTCTCCÄGG

,. "

TCTChCGGGCATGGGCACTCCCTTGGTGGCAAGAGCCCCCTTGACACCGGGGTGGTGGGAACCATGAAGAC
U1

Filed 07/03/2007

AXGAT XGGGGCTGGCCTCTGGCTCTCATGGGGTCCAAGTTTTGTGTATTCTCAACCTATTGACAGACTGAA

ACJ\CAATATGAC

); "..
00 "" 00

Page 12 of 15

Case 1:05-cv-12237-WGY

Document 627-3

Filed 07/03/2007

Page 13 of 15

U.S. Patent

Aug. 15, 1995

Sheet 13 of 27

5,441,868

FIG.

7

:HatAla eTAG AACC¡"TGAG GGTAATAA TAÄTGGCTCC GCCGCGTCTG
TTTGGTACTc CCATTATTTT ATTACCGAGG CGGCGCAGAC
ATCTGCGACT CGAGAG'lTCT GGAACGT'lAC C'GCTGGA1G CTAAGAAGC TAGACGC'lGA GCTCTCAAGA CCTTGCAATG GJtCGACCTTC GATTTCT'lCG

""aI

-1

1

'lGAACATC ACCACTGGTT GTGCTGAACA CTG'lTCTTTG AACGAACA ACTTTGTAG TGGTGACCAA C~CGACTTGT GACAAGAAC TTGCTTTTGT
TTACGGTACC AGACACCAAG GTTAACT'lCT ACGCT'lGGAA ACGTATGGAA AATGCCATGG TCTGTGG'lTC CAATTGAAGA TGCGAACCTT TGCATACCTT
GTTGGTCAAC AAGC1iGTTGA AGTTTGGCAG GGTCTGGCAC TGCTGAGCGA

C1.CCAGTTG TTCGTCAACT TCAACCGTC CCAGACCG'lG ACGACTCGCT
GGCTGTACTG CGTGGCCAGG CACTGCTGGT AACTCCTCl' CAGCCG'IGGG CCGACATGAC GCACCGGTCC GTGACGACCA TTTG1iGGAGA GTCGGCACCC
AACCGCTGCA GCTGCATGTT GACkAGCAG TATCTGGCCT GAGATCTCTG TTGGCGACGT CGAcGTACAA CTGT'ITCGTC ATACACCGGA CTCTAGAGAC

ACTACTCTGC TGCGTGCTCT GGGTGCACAG AAAGAGGCTA TCTCTCCGCC TGATGAGACG ACGCACGAGA CCCACGTGTC TTTCTCCGAT AGAGAGGCGG
GGA'IGC'IGCA TC'IGCTGCAC CGCTGCGTAC C,,TCACTGCT GATACCTTCC CCTACGACG'l AGACGACGTG GCGACGCl~TG GTAGTGACGA CTATGGAAGG

GCAJ'CTGTT TCGTGTATAC TCTAACTTCC TGCGTGGTAA ACTG1i'CTG
CGTTTG1+C1iJ\ 1IGCJ\CATATG :1G1\TTGJ\AGG J.CGCi.CC1\TT TGl.CTTTC1.C

Ball
TATACTGGCG AAGCATGCCG 'l'ÄCTGGTGliC CGCT1\i\TAG ATATGACCGC TTCGTACGGC ATGACCACTG GCGATTì\TCA GCT

Case 1:05-cv-12237-WGY

Document 627-3

Filed 07/03/2007

Page 14 of 15

U.S. Patent

Aug. 15, 1995

Sheet 14 of 27

5,441,868

F1G.8
RinlUII
-i +i

ArgAla

AGCTTGGA'lA AAGAGC'ICC ACCAAGATTG ATCTGTGACT CGAGAG'1TTT AceTAT TTTCTCGAGG TGGTTCTAAC TAGACACTGA GCTCTCAA

GGAAGATAC TTGTTGGAAG C'IAAGAAGC TGAACATC ACCAC'IGGTT CCTTTCTATG AACAACCTTC GATTTCTTCG ACTTTTGTAG TGGTGACCAA
GTGCTGAACA CTGTTCTTTG AACGAACA TTACGGTACC AGACACCAAG CACGACTTGT GACAAGAAC TTGCTTT'lGT AATGCCATGG TCTGTGGTTC

GTTAAC'lTCT ACGCT'IGGAA ACGTATGGAA GTTGGTCAAC AAGCTG'ITGA CAATTGAAGA TGCGAllCCTT TGCATJ.CCTT CAACCAGTTG TTCGACAACT
AGTTTGGCAA GGTTTGGCCT TGTTATCTGA AGCTGTTTTG AGAGGTCAAG 'ICAACCGTT CCAACCGGA ACAATAGACT TCGACAAC TCTCCAG'lTC

CCTTGTTGGT TAACTCT'lCT CAACCATGGG AACCATTGCA ATTGCACGTC GGAACAACCA ATTGAGAAGA GTTGGTACCC TTGGTAACGT TAACGTGCAG

GATAAGCCG TCTCTGGTTT GAGATCTTTG ACTACTTTGT TGAGAGCTTT CTATTTCGGC AGAGACCAA CTCTAGAAC TGATGAAACi\ i\CTCTCGAA
GGGTGCTCAA AAGGAAGCCA TTTCCCCACC AGACGCTGCT TCTGCCGCTC CCC1ICG1\GTT TTCCTTCGGT AAGGGGTGG TCTGCGACGA AGACGGCGAG

CATTGAGAAC CATCACTGCT GATi\CCTTCA GAAGTTATT CAGAGTT'll\C GTAACTCTTG GTAGTGACGA CT1\TGGAAGT CTTTCAATJiA GTCTCAJiTG

TCCAACTTCT TGi\GAGGT1ù ATTGAAGTTG TACACCGGTG AAGCCTGTj\G AGGTTGAAGA ACTCTCCATT TAACTTCAAC ATGTGGCCAC TTCGGACATC
AACTGGTGAC AGATAAGCCC GACTGATMc.C AACAGTGTAG TTGACCACTG TCTJlTTCGGG CTGACTATTG TTGTCACATC

SalI
ATGTAACAA
G

TACATTGTTT CAGCT

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Case 1:05-cv-12237-WGY

FIG.

9

Human

HGVHECPAWLWLLLBLLBLPLGLPVLGAPPRLI CD8RVLERYLLEAKEAENITTGCAEHCSLNENITVPDTK

-20 -10 [phone]

;. c
,!J1

*..**........... ........ ......................... . .. . .............

Monkey

HGVIIECPAWLWLLLBL VBLPLGLPVPGAFPRLICDBRVLERYLLEAKEAENVTHGCBEBCBLNENITVPDTR

~ ~ ~

~ v,

50 60 70 ao 90 100 110
''" "
ro

Document 627-3

Uuman

VNFYANKRMEVGQQA VEVWQGLALLSEA VLRGQALL VNBBQPWEPLQLHVDKA VBGLRBLTTLLRALGAQKE

.................................. . ..... ...... ... ..... .......... .

Monk.ey

VNFYAWKRMEVGQQAVEVWQGLALLBE~ VLRGQA VLANB8QPFEPLQLimDKAIBGLRB ITTLLRALGAQ- E

a

120 130 HO 150 160

-. v
o ~

Human

AI 8 PPDAA8AAPLRTITADTFRKLPRVYBNFLRGKLKL YTGEACRTGDR

... ................. ....................... ...

" "

Filed 07/03/2007

Honkoy

AI 8LPDAABAAPLRTITADTFCKLFRVY8NFLRGRLKL YTGEACRRGDR

Page 15 of 15

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