Association For Molecular Pathology et al v. United States Patent and Trademark Office et al

Filing 171

DECLARATION of Dr. Donna Shattuck in Support re: 61 MOTION for Summary Judgment., 152 MOTION for Summary Judgment.. Document filed by Myriad Genetics, Lorris Betz, Jack Brittain, Arnold B. Combe, Raymond Gesteland, James U. Jensen, John Kendall Morris, Thomas Parks, David W. Pershing, Michael K. Young. (Attachments: # 1 Exhibit 1, # 2 Exhibit 2, # 3 Exhibit 3, # 4 Exhibit 4, # 5 Exhibit 5, # 6 Exhibit 6)(Poissant, Brian)

D

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SHATTUCK DECLARATION EXHIBIT 6

Assembly of BRCA1 transcript from cDNA fragments
1 2

Alu containing exon 4

3 1

Transcripts marked with stars are splice variants which switch reading frames resulting in premature stop codons

Splice variants resulting in truncated BRCA1

1

Skip exon 8 and 9 missing 121 bp

2

Includes exon 4 adding 115 bp

No full length cDNA was identified, the full coding sequence was deduced using non-overlapping fragments

3

Skip exon 8, 9 and 10 missing 3547 bp