Natural Resources Defense Council, Inc. et al v. United States Food and Drug Administration et al

Filing 90

DECLARATION of Lance Price, Ph.D. in Support re: 89 Memorandum of Law in Opposition,. Document filed by Center For Science In The Public Interest, Food Animal Concerns Trust, Natural Resources Defense Council, Inc., Public Citizen, Inc., Union Of Concerned Scientists, Inc.. (Attachments: # 1 Exhibit A)(Sorenson, Jennifer)

EXHIBIT A
TO THE DECLARATION OF
LANCE PRICE, Ph.D.

Lance B. Price, Ph.D.
HOME
101 North Park St.
Flagstaff, AZ 86001
P [phone]
[e-mail]

OFFICE
3051 W. Shamrell Blvd., Ste. 106
Flagstaff, AZ 86001
P [phone]
[e-mail]

EDUCATION
2006

Johns Hopkins University, Baltimore, MD
Doctor of Philosophy in Environmental Health Sciences

2000

Northern Arizona University, Flagstaff, AZ
Master of Science in Biology

1994

Northern Arizona University, Flagstaff, AZ
Bachelor of Science in Microbiology

PROFESSIONAL EXPERIENCE
02/08-Prsnt.

Translational Genomics Research Institute (TGen), Flagstaff, AZ
Associate Professor, Division of Pathogen Genomics (promoted in 2010)
Director, Center for Microbiomics and Human Health
Director, Center for Food Microbiology and Environmental Health

01/07-Prsnt.

Johns Hopkins University Center for a Livable Future, Baltimore, MD
Scientific Advisor

06/09-12/11

Interdisciplinary Health Policy Institute, Flagstaff, AZ
Senior Scientist
Director, Office of Wellness and Healthy Communities

01/09-12/10

Pew Charitable Trusts, Washington, DC
Senior Science Advisor, Pew Campaign on Human Health and Industrial
Farming

01/07-02/08

Johns Hopkins University School of Medicine, Baltimore, MD
Director of Pathogenesis and Molecular Diagnosis of Infectious Diseases

08/03-12/06

Johns Hopkins University, Baltimore, MD
Graduate Research Assistant

12/05-08/06

Pew Commission on Industrial Farm Animal Production, Baltimore, MD
Research Specialist

04/02-08/03 Johns Hopkins University, Baltimore, MD
Research Associate
11/00-04/02

Intralytix, Inc., Baltimore, MD
Research Scientist

09/97-07/00

Keim Genetic Laboratory, Northern Arizona University, Flagstaff, AZ
Research Scientist

01/96-05/97

Northern Arizona University, Flagstaff, AZ
Laboratory Instructor

01/95-05/97

Northern Arizona University, Flagstaff, AZ
Graduate Research Assistant

Lance Price, Page 2 of 7

DISTINCTIONS
Honors

03/08/12

Invited Speaker – US Congressional Briefing on Antimicrobial Resistance.
Washington DC.

04/14/10

Invited Speaker – US House Briefing on Antimicrobial Resistance and Human Health.
Washington DC.

01/13/10

Invited Speaker – Applegate Farms Vendor Summit. Bridgewater, NJ.

12/02/09

Invited Speaker – US House Briefing on Antimicrobial Resistance and Costs to the
Health System. Washington, DC.

07/13/09

Testimony – US House Committee on Antimicrobial Drug Use on Farms. Washington,
DC.

07/07/05

Invited Speaker – US House Briefing on Industrial Animal Production and Public
Health. Washington, DC.

Awards

2003-2005

Predoctoral fellow Award – the Center for a Livable Future, Johns Hopkins School of
Public Health

2004

Best Health Communication Project – the Center for Communications Programs, Johns
Hopkins School of Public Health

2000

Outstanding Master’s Thesis Award – Department of Biological Sciences, Northern
Arizona University

1996

Sustaining Member Travel Grant – American Society for Microbiology

ACTIVITIES
Periodic

External Reviewer – BMC Infectious Diseases, Clinical Microbiology and Infection,
Emerging Infectious Diseases, Environmental Health Perspectives, Genome Research,
MBio, PLoS ONE.

Current

Member – American Public Health Association

Current

Member – American Society for Microbiology

Current

Member – Alliance for the Prudent Use of Antibiotics

2004-2005

Representative – Johns Hopkins School of Public Health Student Assembly

2005-2006

Vice President – Social and Cultural Affairs, Johns Hopkins School of Public Health
Student Assembly

Lance Price, Page 3 of 7

RECENT ORAL PRESENTATIONS
03/28/12

Livestock-Associated MRSA ST398: the birth of a superbug. Knight Science Journalism
at Massachusetts Institute of Technology, Food Boot Camp. Cambridge, MA.

03/12/12

Livestock-Associated MRSA ST398: the birth of a superbug. Johns Hopkins University
School of Public Health. Baltimore, MD.

02/06/12

MRSA ST398: the birth of a superbug. Hvidovre Hospital Seminar Series. Hvidovre,
Denmark.

10/25/11

Livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA): an
emerging threat? Texas A&M Seminar Series. College Station, TX.

10/18/11

Antibiotic-resistant urinary tract infections: a new paradigm for foodborne infections.
FoodMed 2011. Seattle, WA.

10/16/11

Biohunters: How genomic analysis is aiding the fight against bioweapons, global
epidemics and deadly food contaminants. ScienceWriters2011. Flagstaff, AZ.

09/11/11

The origins and evolution of MRSA ST398: through the lens of genome sequencing.
2nd ASM-ESCMID Conference on Methicillin-resistant Staphylococci in Animals:
Veterinary and Public Health Implications. Washington, DC.

09/02/11

Quantifying the human health impacts antibiotic use in food animal production. North
Country Health Grand Rounds. Flagstaff, AZ.

06/23/11

Raised without Antibiotics: Why it matters. Pew Charitable Trusts Headquarters.
Philadelphia, PA.

04/16/11

Multidrug Resistant Staphylococcus aureus in US Meat and Poultry. American Society
for Microbiology Annual Meeting for the Arizona-Southern Nevada Regional Chapter.
Flagstaff, AZ.

04/14/11

Look Who’s Coming to Dinner: Antibiotic Resistant Bacteria in Meat and Poultry.
Science on Tap. Flagstaff, AZ.

03/21/11

Antibiotic use in food animal production: potential impacts on human health. Flagstaff
Medical Center Seminar Series. Flagstaff, AZ.

01/25/11

Public Health Impacts of Antibiotic Use in Food Animal Production: beyond the
traditional foodborne pathogens. Managing the Risk of Foodborne Hazards: STECs
and Antibiotic-Resistant Pathogen Conference. Washington, DC.

11/09/10

Guess Who’s Coming to Dinner? What is Being Detected in Meat and Produce. Pew
Scholars Program 25th Anniversary Reunion, Science and Society Session. Duck Key,
FL.

11/10/10

Prevalence of high-priority antibiotic resistant bacteria in the US food supply. 2010
APHA Annual Meeting and Exposition. Denver, CO.

09/21/10

The Penis Microbiome: Uncovering the Impacts of Circumcision. National Cancer
Institute Meeting on the Human Microbiome and Cancer. Rockville, MD.

Lance Price, Page 4 of 7

09/14/10

Multidrug Resistant Staphylococcus aureus from Food Animals: whole genome
sequence analysis of clonal complex 398. Arrowhead Conference Microbial Genomics
Conference. Lake Arrowhead, CA.

05/29/10

What is going on in the US? PAMTA. APUA Roundtable: Strengthening Scientific
Evidence to Control Misuse of Antibiotics in Agriculture. Paris, FR.

05/04/10

Antibiotic Resistant Bacteria from Food Animal Production. Pew Charitable Trusts:
Field Team Education and Traning. Washington, DC.

04/21/10

Briefing on the Preservation of Antibiotics for Medical Treatment Act (PAMTA).
MedChi’s Public Health Committee, Maryland State Medical Society. Baltimore, MD.

PUBLICATIONS
Peer-Reviewed Manuscripts
Price LB, Stegger M, Hasman H, Aziz M, Larsen J, Andersen PS, Pearson T, Waters AE, Foster JT,
Schupp J, Gillece JG, Driebe E, Liu CM, Springer B, Zdovc I, Battisti A, Franco AF, Żmudzki J,
Schwarz S, Butaye P, Jouy E, Pomba C, Porrero C, Ruimy R, Smith TC, Robinson A, Weese S,
Arriola CS, Yu F, Laurent F, Keim P, Skov R, and Aarestrup F. Staphylococcus aureus CC398: host
adaptation and emergence of methicillin resistance in livestock. MBio. 2012 Feb 21;3(1). pii:
e00305-11.
Stegger M, Price LB, Larsen A, Gillece JG, Waters AE, Skov R, and Andersen PS. Genome
Sequence of Staphylococcus aureus Strain 11819-97, an ST80-IV European Community-Acquired
Methicillin-Resistant isolate. J. Bacteriol. 2012. Mar;194(6):1625-6.
Liu CM, Aziz M, Kachur S, Watson L, Hsueh P, Huang YT, Keim P, Price LB. AllBactQuant: An
enhanced broad-coverage bacterial quantitative real-time PCR assay targeting the 16S rRNA gene.
BMC Microbiol. In Press.
Johnson JR, Tchesnokova V, Johnston B, Clabots C, Roberts PL, Billig M, Riddell K, Rogers P, Qin X,
Butler-Wu S, Price LB, Aziz M, Nicolas-Chanoine M, DebRoy C, Castanheira M, Robicsek A, Hansen
G, Urban C, Platell J, Trott D, Zhanel G, Weissman SJ, Cookson BT, Fang FC, Limaye A, Scholes D,
Chattopadhyay S, Hooper DC, the RESIST Study Group*, and Sokurenko EV. Emergence of a Single
Dominant Multi-Drug-Resistant Strain of Extraintestinal Escherichia coli from Sequence Type
ST131. Lancet Infect Dis. Under review.
Peterson AE, Davis MF, Awantang G, Julian KG, Greene WH, Doppalapudi A, Price LB, Waters A,
Krain LJ, Nelson LJ, Silbergeld EK, Whitener CJ. Molecular and phenotypic characteristics of
health care- and community-associated methicillin-resistant Staphylococcus aureus (MRSA) at a
tertiary care center in Pennsylvania, 2009-2010. PLoS ONE. Accepted.
Keim PS, Aarestrup FM, Shakya G, Price LB, Hendriksen RS, Engelthaler DM, Pearson T. Reply to
"South Asia instead of Nepal may be the origin of the Haitian cholera outbreak strain". MBio. 2011
Nov 1;2(6):e00245-11. doi: 10.1128/mBio.00245-11.
Davis MF, Baron P, Price LB, Williams D, Jeyaseelan S, Hambleton I, Diette GB, Breysse PN,
McCormack MC. Dry collection and culture methods for recovery of methicillin-susceptible and
methicillin-resistant Staphylococcus aureus from indoor home environments. Appl Environ
Microbiol. 2012 Jan 27.
Engelthaler DM, Bowers J, Schupp J, Pearson T, Ginther J, Hornstra HM, Dale J, Stewart T, Komatsu
K, Sunenshine R, Waddell V, Levy C, Gillece J, Price LB, Contente-Cuomo T, Beckstrom-Sternberg

Lance Price, Page 5 of 7

S, Blaney DD, Wagner DM, Mayo M, Currie BJ, Keim PS, Tuanyok A.. Molecular investigations of a
locally acquired case of melioidosis in Southern AZ. PLoS Negl Trop Dis. 2011 Oct;5(10):e1347.
Hendriksen RS, Price LB, Schupp J, Gillece J, Kaas RS, Engelthaler DM, Bortolaia V, Upadhyay BP,
Pearson P, Waters AE, Shrestha SD, Adhikari S, Shakya G, Keim PS, Aarestrup FM. Population
genetics of Vibrio cholerae from Nepal, year 2010: An identical clone in Nepal and the Haiti
outbreak. MBio. 2011 2(4): doi:10.1128/mBio.00157-11.
Liu CM, Cosetti MK, Aziz M, Buchhagen JL, Contente-Cuomo TL, Price LB, Keim PS, Lalwani AK.
The Otologic Microbiome: A study of the bacterial microbiota in a pediatric patient with chronic
serous otitis media using 16S rRNA gene-based pyrosequencing. Arch Otolaryngo Head Neck Surg.
2011. Jul;137(7):664-8.
Davis MF, Price LB, Liu CM, Silbergeld E. An ecological perspective on U.S. industrial poultry
production: the role of anthropogenic ecosystems on the emergence of drug-resistant bacteria from
agricultural environments. Current Opinions in Microbiology. 2011. Curr Opin Microbiol. 2011
Jun;14(3):244-50.
Waters A, Contente-Cuomo T, Buchhagen J, Liu CM, Watson L, Pearce K, Foster JT, Bowers J,
Driebe E, Engelthaler D, Keim PS, Price LB. Multidrug Resistant Staphylococcus aureus in US
Meat and Poultry: Evidence for animal origins. Clin Infect Dis. 2011; 52(10):1227-30.
Hardy CG, Leila Lackey LG, Cannon J, Price LB, and Silbergeld EK. Prevalence of potentially
neuropathic Campylobacter jejuni strains on commercial broiler chicken products. Int J Food
Microbiol. 2011; 145:395-9.
Price LB, Liu CM, Frankel YM, Melendez JH, Aziz M, Buchhagen J, Contente-Cuomo T,
Engelthaler DM, Keim PS, Ravel J, Lazarus GS, and Zenilman JM. Macro-scale spatial variation in
chronic wound microbiota: a cross-sectional study. Wound Repair Regen. 2011; 19(1):80-8.
Chen PE, Willner KM, Butani A, Dorsey S, George M, Stewart A, Lentz SM, Cook CE, Akmal A,
Price LB, Keim PS, Mateczun A, Brahmbhatt TN, Bishop-Lilly KA, Zwick ME, Read TD,
Sozhamannan S. Rapid identification of genetic modifications in Bacillus anthracis using whole
genome draft sequences generated by 454 pyrosequencing. PLoS ONE. 2010; 5(8):e12397.
Wagner DM, Runberg J, Vogler AJ, Lee J, Driebe E, Price LB, Engelthaler DM, Fricke WF, Ravel J,
Keim P. No resistance plasmid in Yersinia pestis, North America. Emerg Infect Dis. 2010; 16:885-7.
Silbergeld E, Davis M, Feingold B, Goldberg A, Graham J, Leibler J, Peterson A, Price LB. New
infectious diseases and industrial food animal production. Emerg Infect Dis. 2010; 16:1503.
Price LB, Liu CM, Johnson KE, Aziz M, Lau MK, Bowers J, Ravel J, Keim PS, Serwadda D, Wawer
MJ and Gray RH. The effects of circumcision on the penis microbiome. PLoS ONE. 2010;
5(1):e8422.
Melendez JH, Frankel YM, An AT, Williams L, Price LB, Wang NY, Lazarus GS, and Zenilman JM.
Real-Time PCR Assays compared to Culture-Based Approaches for Identification of Aerobic
Bacteria in Chronic Wounds. Clin Microbiol Infect. 2010; 16:1762-9.
Frankel YM, Melendez JH, Wang N, Price LB, Zenilman JM, Lazarus GS. Wound microbial flora:
molecular microbiology unlocks new horizons. Arch Dermatol. 2009; 145:1193-5.

Lance Price, Page 6 of 7

Price LB, Liu CM, Melendez JH, Frankel YM, Engelthaler D, Aziz M, Bowers J, Rattray R, Ravel J,
Kingsley C, Keim PS, Lazarus GS, Zenilman JM. Community analysis of chronic wound bacteria
using 16S rRNA gene-based pyrosequencing: impact of diabetes and antibiotics on chronic wound
microbiota. PLoS One. 2009; 31:e6462.
Graham JP, Evans SL, Price LB, Silbergeld. Fate of antimicrobial-resistant enterococci and
staphylococci and resistance determinants in stored poultry litter. Environ Res. 2009; 109:682-9.
Graham JP, Price LB, Evans SL, Graczyk TK, Silbergeld EK. Antibiotic resistant enterococci and
staphylococci isolated from flies collected near confined poultry feeding operations. Sci Total
Environ. 2009; 407:2701-10.
Vogler AJ, Birdsell D, Price LB, Bowers JR, et al. Phylogeography of Francisella tularensis: Global
Expansion of a Highly Fit Clone. J Bacteriol. 2009; 191:2474-84.
Graham, JP, Tuchmann JL, Price LB, Otte JM, Pfeiffer DU, Tiensin T, and Silbergeld EK. The
Animal:Human Interface and Infectious Disease in Industrial Food Animal Production: Rethinking
Biosecurity and Biocontainment. Public Health Reports. 2008; 123:282-299.
Silbergeld EK, Graham J, and Price LB. Industrial Food Animal Production, Antimicrobial
Resistance, and Human Health. Annu. Rev. Public Health. 2008; 29:151–69.
Price LB, Graham JP, Lackey L, Roess A, and Silbergeld E. Multidrug resistant Escherichia coli
among US poultry workers. Environ Health Perspect. 2007; 115:1738-1742.
Price LB, Lackey L, Vailes R and Silbergeld E. 2007. The persistence of fluoroquinolone-resistant
Campylobacter in poultry production. Environ Health Perspect. 115:1035–1039.
Price LB, Roess A, Graham JP, Baqar S, Vailes R, Sheikh KA, and Silbergeld E. Neurologic
symptoms and neuropathologic antibodies in poultry workers exposed to Campylobacter jejuni. J
Occ Environ Med. 2007; 49:748-55.
Chapin Sapkota AR, Price LB, Silbergeld EK and Schwab KJ. Arsenic Resistance in Campylobacter
spp. Isolated from Retail Poultry Products. Appl Environ Microbiol. 2006; 72:3069-7.
Nachman, KE, Graham JP, Price LB and Silbergeld EK. Arsenic: a roadblock to potential animal
waste management solutions. Environ Health Perspect. 2005; 113:1123-4.
Price LB, Johnson E, Vailes R and Silbergeld E. Fluoroquinolone resistant Campylobacter from
antibiotic-free and conventional poultry products. Environ Health Perspect. 2005; 113:557-60.
Price LB, Vogler A, Pearson T, Busch JD, Schupp JM and Keim P. In Vitro Selection and
Characterization of Bacillus anthracis Mutants with High-Level Resistance to Ciprofloxacin.
Antimicrob. and Chemother. 2003; 47:2362-2365.
Klevytska, AM, Price LB, Schupp JM, Worsham P, Wong J and Keim P. Identification and
characterization of variable-number tandem repeats in the Yersinia pestis genome. J. Clin.
Microbiol. 2001; 39:3179-3185.
Jubrias SA, PC Esselman, LB Price, ME Cress, Conley KE. Large Energetic adaptations of elderly
muscle to resistance and endurance training. J. Appl. Physiol. 2001; 90:1663-1670.
Smith KL, DeVos V, Bryden H, Price LB, Hugh-Jones ME and Keim P. Bacillus anthracis diversity
in Kruger National Park. J. Clin. Microbiol. 2000; 38:3780-3784.

Lance Price, Page 7 of 7

Price LB and Shand RF. Halocin S8: A 36 amino acid haloarchaeal microhalocin. J. Bacteriol.
2000; 182:4951-4958.
Schupp JM, Klevytska AM, Price LB, Zinser G and Keim P. VrrB: A hypervariable ORF in Bacillus
anthracis. J. Bacteriol. 2000; 182:3989-3997.
Keim P, Price LB, Klevytska AM, Smith KL, Schupp JM, Okinaka R, Jackson P and Hugh-Jones
ME. Multiple-Locus VNTR analysis (MLVA) reveals genetic relationships within Bacillus anthracis.
J. Bacteriol. 2000; 182:2928-2936.
Keim P, Klevytska AM, Price LB, Schupp JM, Zinser G, Smith KL, Hugh-Jones ME, Okinaka R,
Hill KK and Jackson PJ. Molecular diversity in Bacillus anthracis. J. Appl. Microbiol. 1999; 87:2157.
Smith KL, De Vos V, Bryden HB, Hugh-Jones ME, Klevytska A, Price LB, Keim P and Scholl DT.
Meso-scale ecology of anthrax in southern Africa: a pilot study of diversity and clustering. J. Appl.
Microbiol. 1999; 87:204-7.
Schupp, JM, Price LB, Klevytska A and Keim P. Internal and flanking sequence from AFLP
fragments using ligation-mediated suppression PCR. Biotechniques. 1999; 26:905-10.
Price LB, Hugh-Jones M, Jackson PJ and Keim P. Genetic diversity in the protective antigen gene
of Bacillus anthracis. J Bacteriol. 1999; 181:2358-62.
Porter TL, Eastman MP, Hagerman ME, Price LB, and Shand RF. Site-specific prebiotic
oligomerization reactions of glycine on the surface of hectorite. J. Mol. Evol. 1998; 47:373-377.
Cheung J, Danna KJ, O’Connor EM, Price LB, and Shand RF. Isolation, sequence, and expression
of the gene encoding halocin H4, a bacteriocin from the halophilic archaeon Haloferax
mediterranei R4. J. Bacteriol. 1997; 179:548-551.
Schupp, J M, Travis SE, Price LB, Shand RF and Keim P. Rapid bacterial permeabilization reagent
useful for enzyme assays. Biotechniques. 1995; 19:18-20.
Online Reports
Otte J, Pfieffer D, Silbergeld E, Price L, and Tiensin T. HPAI risk, biosecurity, and small holder
adversity. FAO Policy Brief, 2006. http://www.fao.org/ag/againfo/projects/en/pplpi/hpai.html
Book chapters
Shand RF, Price LB, and O’Connor EM. 1999. Halocins: protein antibiotics from hypersaline
environment. In, A. Oren and R.H. Vreeland (ed.), Microbiology and biogeochemistry of hypersaline
environments. CRC Press, Inc., Boca Raton.