Amgen Inc. v. F. Hoffmann-LaRoche LTD et al

Filing 567

DECLARATION of Linda A. Sasaki-Baxley in Support of Amgen Inc.'s Opposition to Roche's Motion for Summary Judgment That Claim 1 of the '422 Patent is Invalid Under 35 U.S.C. Sec. 112 by Amgen Inc.. (Attachments: #1 Exhibit Ex. A#2 Exhibit Ex. B#3 Exhibit Ex. C)(Rich, Patricia)

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Amgen Inc. v. F. Hoffmann-LaRoche LTD et al Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 1 of 15 Dockets.Justia.com 211 .S CSU 53 rednU dilavnI si tnetaP 224' fO 1 mialC taht tnemgduJ yrammuS rof noitoM s'ehcoR oT noitisoppO s'negmA fo troppuS ni .lceD yelxaB A TIBIHXE Doc. 567 Att. 1 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 8077 .ON .R.S.C ,retlaP nalA yrraH :yb detropeR ).redro evitcetorp eht htiw ecnadrocca ni tpircsnart eritne eht taert .redrO evitcetorP dednemA esaelP eht fo )c(5 noitceS rep sa laitnedifnoc detangised ynomitset sniatnoc tpircsnart sihT( 7002 AINROFILAC I .D.HP ,82 HCRAM EKALTSEW ,EGALLIV EMULOV FO ,NIL NEUK-UF NOITISOPED DEPATOEDIV .stnadnefeD ,noitaroproC ,.DTL YGW-73221-VC-50 .oN yesreJ weN a ,.CNI ,EHCOR AL-NNAMFFOH dna ,ynapmoC namreG a ,HbmG SCITSONGAID ,ynapmoC ssiwS a EHCOR ,EHCOR AL-NNAMFFOH .F oV noitcA liviC ,ffitnialP ,.CNI ,NEGMA yp oC deifitreC 7002/8213 STTESUHCASSAM TRUOC TCIRTSID FO TCIRTSID DETINU SETATS LAITNEDIFNOC emuloV- .D.hP ,niL 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etoNeviL 52 42 32 21 hguorht .son CTI-MA CTI-MA te 571 98.11.8 06031100 90031100 setaB ,.la ,.cte ,lacituecamrahP iaguhC detad .sv negmA ni tprecxe lairT TIBIHXE 22 651 teehsdaerps )21-1 .SON( roloc nodoC ii TIBIHXE 12 seirotagorretnI fo teS tsriF 0i TIBIHXE 02 91 'stnadnefeD 721 ot esnopseR .S.U .S.U .S.U .S.U .S.U .S.U latnemelppuS s'ffitnialP 224,559,5 080,126,5 943,657,5 896,816,5 339,745,5 868,144,5 .oN .oN .oN .oN .oN .oN 13 13 13 tnetaP tnetaP tnetaP tnetaP tnetaP tnetaP 9 8 7 TIBIHXE TIBIHXE TIBIHXE TIBIHXE TIBIHXE TIBIHXE 81 71 61 51 41 31 13 13 13 6 5 4 ffodzorD morf samohT 0I rimidalV 3 TIBIHXE 21 ii 0i 9 2 ot edeaG .G mailliW 70.31.3 detad retteL gniMelF morf dna nosraC aicirtaP ot edeaG .G mailliW 70.6.3 detad retteL ot TIBIHXE 8 )6( )b(03 eluR negmA ot 0i tnausruP noitisopeD 'stnadnefeD 1 TIBIHXE 7 6 fo ecitoN tsriF EGAP NOITPIRCSED STIBIHXE OT XEDNI # HXE 5 4 3 8077 .oN RSC ,retlaP .sv .A yrraH 2 1 7002 ,82 hcraM ehcoRaL-namffoH I ,yadsendeW negmA NEUK-UF EMULOV ,.D.HP ,NIL 7002/82/3 LAITNEDIFNOC emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 6 of 15 6 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 52 42 32 22 12 02 91 81 71 61 51 41 31 21 ii 0i CTI-MA CTI-MA te 78631100 hguorht 20631100 .son setaB ,.la 9 8 51 ,.cte detad ,lacituecamrahP TIBIHXE 212 98.12.8 iaguhC .sv negmA ni tprecxe lairT hguorht 60631100 20631100 7 6 5 4 CTI-MA CTI-MA te ,.cte detad .son setaB ,.la ,lacituecamrahP .sv negmA ni tprecxe lairT iaguhC 881 98.12.8 41 TIBIHXE 3 2 31 .son 681 morf 28617100 CTI-MA ot 08617100 CTI-MA setaB ,niL neuK-uF 28.22.11 detad omeM TIBIHXE 1 LAITNEDIFNOC 7002/82/3 emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 7 of 15 7 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 03:81:90 72:81:90 22:81:90 12:81:90 81:81:90 61:81:90 01:81:90 70:81:90 30:81:90 20:81:90 85:71:90 75:71:90 35:71:90 15:71:90 54:71:90 24:71:90 ta no ecalp gnikat si nekat dna tnadnefed eht fo flaheb 52 42 gnieb si noitisoped s'yadoT .ecivreS flaheb no 32 22 dlroW etoNeviL fo dna gnitroper nosluaP ehT truoc ,secivreS fo noitagitiL yrraH si gnitropeR retlaP 12 02 yadot retroper .0032-123 )514( naS 91 81 71 61 rebmun enohP .50149 ainrofilaC ,ocsicnarF ta ,0521 etiuS ,teertS niaM 122 detacol ,ecivreS dlroW etoNeviL enairdA gnitneserper ehT ,ortsaC si yadot rotarepo oediv 51 .M.A 61:9 41 31 21 ii 0i 9 8 7 si rotinom oediv .82 eht no emit etad eht dnA hcraM VC si s'yadoT .,sttesuhcassaM .S.U .YGW 73221 50 rebmun esac fo ni tcirtsiD ,truoC tcirtsiD eht eht 93:71:90 43:71:90 33:71:90 10:71:90 10:71:90 ,ehcoRaL-namffoH ,I emulov susrev negmA fo rettam ni ,i epat ,.D.hP eht ,niL neuK-uF ereH EHT .rD fo noitisoped depatoediv .drocer no snigeb er'eW :REHPARGOEDIV 6 5 4 .M.A 61:9 3 2 1 7002 ,82 HCRAM ,YADSENDEW EKALTSEW AINROFILAC ,EGALLIV LAITNEDIFNOC 7002/82/3 emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 8 of 15 8 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 52 42 62:91:90 81:91:90 32 .ssentiw truoc eht ni raews esaelp retroper EHT 22 12 71:91:90 31:91:90 11:91:90 90:91:90 eht dluoW :REHPARGOEDIV .cnI ,negmA 02 rof drofetihW ydneW ym :DROFETIHW .SM 91 .namdloG 81 71 70:91:90 50:91:90 30:91:90 00:91:90 85:81:90 65:81:90 55:81:90 25:81:90 15:81:90 eirreB ,eugaelloc htiw .niL ereh m'I .rD no neuK-uF ,ssentiw reebesaC 61 51 41 eht dna ,.cnI ,negmA fo flaheb yaD fo dirdaM divaD :DIRDAM .RM .stnadnefed rof .SM relohcS 31 21 eyaK fo nanooN elleinaD .stnadnefed :NANOON rof relohcS .RM eyaK fo ii 0i osla ,kinehceP maharG :KINEHCEP .sevlesmeht ohw ecudortni dnA lliw 9 94:81:90 94:81:90 64:81:90 seugaelloc owt era em htiw .ehcoR 8 7 gnitneserper m'I .SM ,relohcS eyaK morf imA-neB .seY aroeL 6 5 etats 54:81:90 :IM·-NEB 34:81:90 14:81:90 73:81:90 .tneserper uoy ohw dna 4 sevlesruoy .26319 ecudortni esaelp ,lesnuoC ekaltseW snosaeS 3 ainrofilaC ,mooR ekaltseW ,egalliV ,letoH ,evirD eht 2 1 23:81:90 eloD 2 ruoF 7002/82/3 LAITNEDIFNOC emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 9 of 15 9 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 64:91:90 64:91:90 54:91:90 34:91:90 14:91:90 ?erofeb desoped neeb ev'uoY 52 .yakO .od I ?kaerb taht evah a Q A 42 32 22 ,seY fi ekat taht ot deen uoy ,ytinutroppo dnA fO uoy dnatsrednu uoy 12 04:91:90 04:91:90 83:91:90 .esruoc Q ot 02 emit 91 81 .sey morf ,emit tuB ,skaerb ekat ot deen dluow I 63:91:90 43:91:90 33:91:90 33:91:90 13:91:90 03:91:90 tonnac .oN A 71 61 51 ?ssenderitrevo on ;nosaer lacidem oN .oN Q A ?yadot yfitset uoy taht nosaer 41 31 yna ereht sI .rotcoD ,gninrom dooG :IMA-NEB Q .SM YB 21 II 0I 92:91:90 92:91:90 92:91:90 82:91:90 82:91:90 72:91:90 NOITANIMAXE 9 .uoy knahT :IMA-NEB .SM EHT 8 7 6 :swollof .nigeb esaelP :REHPARGOEDIV 5 4 sa deifitset erudecorP ni htao na dna denimaxe fo saw ,4902 noitceS liviC edoC htiw ecnadrocca neeb 3 2 1 deretsinimda ylud gnivah ,.D.HP ,NIL NEIIK-UF LAITNEDIFNOC 7002/82/3 emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 10 of 15 77 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 44:95:01 34:95:01 24:95:01 .noitcejbO .tcerroc :DIRDAM .RM 52 A syawla uoy s'ti ,oN 42 32 22 12 ?tcerrocni saw 04:95:01 73:95:01 63:95:01 taht .sey taht ,eneg enimreted eht morf did nehW Q decuded s'tahT s'tahT 661 A .thgir ?sdica ni ecneuqes 02 91 81 71 61 51 23:95:01 92:95:01 62:95:01 onima eht si 6 erugif uoy dica onima taht uoy desolcsid Q ,stnetap eht ni taht llacer ,lleW 62:95:01 22:95:01 02:95:01 71:95:01 71:95:01 41:95:01 ·.1:95:0i 70:95:01 30:95:01 65:85:01 saw .wonk taht nehw t'nod I t'nod I uoy tuB .denimreted A wonk ?taht denimreted dah ,4891 41 31 ,03 rebmevoN yb ,saw noitseuq ym .yakO .sey Q 21 ii ,561 sa ew stsixe ti tuB neve .denimreted ton evah hguoht ,eneg eht 0i 9 8 7 yb ,sllec eht yb desserpxe sa s'ti nehw ,flesti eht A tcudorp eht ew ni nehw stsixe wonk ecneuqes tub ,taht denimreted t'nod I 55:85:01 05:85:01 64:85:01 54:85:01 44:85:01 44:85:01 ?snaem ?sdica onima eht taht 561 6 5 4 3 2 si OPE namuh fo erutcurts oS .seY yramirp enimreted negmA did nehw taht tahw taht sI A .tcerroc s'tahT 1 7002/82/3 LAITNEDIFNOC emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 11 of 15 87 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 12:00:11 91:00:11 ?4891 ,03 oS rebmevoN 52 42 retfa denrael ylno taht saw 61:00:11 61:00:11 31:00:11 0I:00:iI 70:00:11 40:00:11 40:00:11 30:00:11 .yakO .sey Q 32 sa ,561 22 12 02 sllec ew eht yb edam saw ti wenk ew eW .ti ecneuqes ecneuqes ,nietorp hguone ew evah nehw ,no evah ,nietorp onima eht .evah eht ew retal A ,nehw 91 81 71 sdica lautca ehT ?ti si tahW .decuded 61 51 10:00:ii 10:00:iI 85:95:01 ton ,si ti tahw uoy gniksa m'I tuB .yakO .eneg Q A 41 31 OPE eht morf decuded sA 661 65:95:01 35:95:01 25:95:01 25:95:01 ?sdica namuh onima eht oS si 21 iI fo ecneuqes dica onima Q .SM YB :IMA-NEB .tcerroc .tcerroc 0I 9 si 661 EHT I 15:95:01 05:95:01 05:95:01 74:95:01 s'tI .seY :SSENTIW 8 7 .ecneuqes .raelc eb ot tnaw 6 5 4 dica onima eht tuoba .oN gniklat :IMA-NEB m'I .SM .tcerroc 74:95:01 64:95:01 54:95:01 54:95:01 3 2 1 syawla si eneg ehT :SSENTIW EHT .noitcejbO 7002/82/3 LAITNEDIFNOC emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 12 of 15 322 egaP 1 .txE 8663.845.008 ecivreS dlroW etoNeviL 60:92:51 40:92:51 20:92:51 85:82:51 55:82:51 35:82:51 94:82:51 94:82:51 s'tI ?thgir esuaceb .661 ;ecneuqes redael s'tI eht sah ti 52 42 32 22 12 ,tahtnaht reggib s'tI neve Q .eneg s'tI eht yb deificeps si :eneg eht yb eht edam sa .561 etalosi uoy tcudorp yb edam sA A .tcerroc s'taht ,haeY 02 91 81 71 ?thgir ;sdica onima ni debircsed si taht 561 sah ylno noitacificeps ni deterces eht oS eht 64:82:51 14:82:51 63:82:51 ssecorp OPE eht yllautca Q ssecorp tnanibmocer 61 51 41 31 21 ii .gniterces eht ni devomer tub eht fo 33:82:51 92:82:51 52:82:51 22:82:51 12:82:51 31:82:51 90:82:51 50:82:51 20:82:51 00:82:51 95:72:51 85:72:51 si dica si onima tsal eht ,wohemos onima otni ,661 osla eno ylbaborp s'ti ,eneg .eneg dica gnikam gnikam nehw ,sllec eht eht eht oS detcefsnart s'ti morf ni decuded detats A 0i 9 8 sa sa dica onima OPE 661 si ,6 erugif ehT ,ecneuqes ?tcerroc 561 namuh erutam ;seudiser dica onima deificeps sedulcni onima OPE 7 6 5 ylno dica namuh erutam eht fo ecneuqes eht ,tcaf nI Q .SM YB :IMA-NEB 4 .yaw tnereffid a ti ksa ll'I .SM 3 2 1 75:72:51 65:72:51 .yakO :IMA-NEB .suougibma dna eugaV 7002/82/3 LAITNEDIFNOC emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 13 of 15 282 egaP 1 .txE 8663·845·008 ecivreS dlroW etoNeviL 52 42 32 12 02 91 81 71 .D.hP ,niL neuK-uF 61 51 41 31 .ainrofilaC ta 21 ii 0i 02 fo .tcerroc yad dna eurt siht DETAD sa si ym ,detcerroc taht raeppa ;em sa ,niereh 9 8 7 6 5 4 deniatnoc sa ynomitset ,niereh evah I fo yb delaitini snoitcerroc hcraM eht nekat daer ,kni ni hcus edam deton taht ;7002 ,82 noitisoped evah I ym tpircsnart gniogerof fo taht yrujrep ,.D.hP ytlanep neuK-uF rednu yfitrec ybereh od ,niL ,I 3 2 YRUJREP FO YTLANEP REDNU NOITARALCED 1 LAITNEDIFNOC 7002/82/3 emuloV- .D.hP ,niL neuK-uF fo noitisopeD )6()b(03 Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 14 of 15 52 42 8077 ".oN RSC ,retlaP nalA yrraH 32 22 12 02 91 ym debircsbus evah I ,FOEREHW SSENTIW NI · · · siht eman 81 71 61 .emit dna taht taht eurt ta-nekat a sgnideecorp eht 51 41 ynomitset eht fo drocer si gniogerof ;noitcerid ym rednu otni debircsnart noitpircsnart dedia-retupmoc dna em 31 21 11 01 9 retal erew yb yllacihpargonets dna detroper eht taht sgnideecorp ynomitset edoC ;4902 noitceS htao erudecorP liviC fo htiw ecnadrocca ni eht fo na deretsinimda ylud eht ,noitisoped noitisoped tnemeclremmoc erofeb ,saw 8 7 gniogerof eht ni deman ssentiw eht tahT 6 :yfitrec ybereh od 5 ,ainrofilaC fo etatS eht rof dna ni ,retropeR 3 2 dnahtrohS deifitreC ,retlaP nalA yrraH ,I NOITACIFITREC S'RETROPER I Case 1:05-cv-12237-WGY Document 567-2 Filed 06/29/2007 Page 15 of 15

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