Amgen Inc. v. F. Hoffmann-LaRoche LTD et al

Filing 534

DECLARATION re #532 Memorandum in Support of Motion, #531 MOTION for Summary Judgment That Dr. Lin's Asserted Claims are Definite, Adequately Described and Enabled BY RENEE DUBORD BROWN by Amgen Inc.. (Attachments: #1 Exhibit Ex. 1#2 Exhibit Ex. 2 - 1#3 Exhibit Ex. 2-2#4 Exhibit Ex. 2-3#5 Exhibit Ex. 2-4#6 Exhibit Ex. 3-1#7 Exhibit Exhibit 3-2#8 Exhibit Ex. 3-3#9 Exhibit Ex. 4-1#10 Exhibit Ex. 4-2#11 Exhibit Ex. 4-3#12 Exhibit Ex. 5-1#13 Exhibit Ex. 5-2#14 Exhibit Ex. 5-3#15 Exhibit Ex. 5-4#16 Exhibit Ex. 6-1#17 Exhibit Ex. 6-2#18 Exhibit Ex. 6-3#19 Exhibit Ex. 6-4#20 Exhibit Ex. 6-5#21 Exhibit Ex. 7#22 Exhibit Ex. 8#23 Exhibit Ex. 9#24 Exhibit Ex. 10#25 Exhibit Ex. 11#26 Exhibit Ex. 12#27 Exhibit Ex. 13#28 Exhibit Ex. 14#29 Exhibit Ex. 14#30 Exhibit Ex. 16#31 Exhibit Ex. 17#32 Exhibit Ex. 18#33 Exhibit Ex. 19#34 Exhibit Ex. 20#35 Exhibit Ex. 21#36 Exhibit Ex. 22#37 Exhibit Ex. 23#38 Exhibit Ex. 24#39 Exhibit Ex. 25)(Gottfried, Michael)

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Amgen Inc. v. F. Hoffmann-LaRoche LTD et al Doc. 534 Att. 24 Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 1 of 11 EXHIBIT 10 Dockets.Justia.com 56238900 CTI-MA 895891076MA WXB tibihxE iaHT YGW-41801-79 yveL .I evat�uG eaO ,�et�eC ltctdeM taaiS tnuoM ,�Iiuo�aZ .G .92001 (�1 �ixoY weN ,ecalP �dahC .�D ot �t�euqm tnirpe� �exddA .1�91 ,91 yumnaJ detpecca ;0�1,6 rebmeceD noitacilbup rof devieceR htiw stneitap fo eniru eht morf PE hcnuh fo noitacifirup ehT .evitdnesni dna ,emosrebmuc ytluciffid ,]8-5[ dezdehtnj� eb ot �aeppa PE erehw ,]4-1[ �yendik fo stcartxe morf )PE( niteloporhtyre evitcaotb ,deifirup fo �eltitnauq �rel niatbo ot ytilibani eht fo esuaceB NOITCUDORTNI ,gnimumoc-emit era �ya�sa hcuS .]81-- 11[ PE fo tnemerusaem � �of elbaliava neeb evah yas�a noiti�lni noita�itelggameh a dna �ya�aoib erutluc-llac rO lamina elohw ylno ,y]tnec -er litnU .]0I-8[ sdeioporhty�e fo rotalumits roj�m eht eb ot ylekil si hcihw ,enomroh erusaem ot �yana evitisn� fo tnempoleved eht ni deretnuocne neeb sah aietmpocy]8 hht .sisoiopotameh ni PE fo ecnatropmi eht fo �nidnatsrednu ruo esserc o� hcihw nopu krow�marfyra�eecen eht dedivorp sah &IR elbailer ,elpnhs sihT .secnatsmucric tsom ni PB fo s�itartn�cnoc mu�es lamro� morf desaerc �ed etanim/rosid o� oka tub aimena citsalpa ni dnuof slevel PE mures detawele eht etat�tnauq o� ylno ton yticificeps dna ytivitisnes tneiciffus sah depoleved evahew taht yas�onummi PE ehT .PE yraniru dradnats ot r�imia �aw mur�s ni derusaem PE ,aifuti�c cihpargotamorhc le� dna cigolonummi yB .slamron fo taht deppalrevo )lm/Um � |-81�( �nar eht {ub ,slaudlvldn/lamron naht )lm/Um 5.04( noitartnecnoc � �res naem reh�ih a dah eruliaf laner cinorhc htiw stneitap nevai� Lm/Um � 1� ,snoitartnecnoc p.F elbatc-�t�dnu ylfn�tslsnoc dah arev aimehtycyloP htiw stneitap ,AIR siht nI .lm/Um 434,6-489 �a&r ,lm/Um 784,3 fo eulav naem a htiw �noitaxtnecnoc PE mures delavele yldekram d�h aimena citss|pa ereves htiw stneitap enin ,tsartnoc nI Lm//lm 92 fo eulav naem a htiw lm/Um t8 ot 81< morf de�nar �]audividni lamron ni p.�i fo oit -artnecnoc mu�es eht ;ebut yae�a eht ni PE fo.lm/Um 5 tcet�d nac-,noitagi�s�," -ni �ht ni deb'ncsed PE rof AIR ehT .)AIR( ya�aonummioidar PE na fo tnem -po1eved eht rof de�ttqer )�m/U 000,0/�'�( P.P evitcaoib ylhgih fo seititnauq llams dedivorp sah )'IH( .nite�porhtyre namuh fo noitacifirup ehT .ev�isnesni dna �nimu.�noc-emit ,emomebmuc e�e ,nifeiopo�ht�e namuh rof sy�aoiB kroY llemoC dnar retneC weN ,egelloC lacideM wdrevtnU sediruoK �A enol dna ,nanrffoH �ec�aC gnirmeK-naotS lairomeM .J hteB ,siluoraZ .G selrahC eruliaF laneR cinorhC dna sredrosiD ni cigolotameH niteioporhtyrE yassaonummloidaR yb derusaeM slroitab!recnoC mureS fo Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 2 of 11 66238900 CTI-MA 995891076MA fo �c �&6 X 5.1 a no d�pa�tamorhc� ne� �w � det�doi fo �ah � � .52� �d�peS f0 �uloc m�2 X 5.1 a � yhp�ta�c 1� �Iut detcaer� mo� det� � � deta�i e� .]82[ �S d� �F yb d� do� �G .�t � fo ts� d�u � y�t�o�c 52� �p� y� �neuq �s ,t�cif�is ton �w noit�e�a � ,rwe� .)1 .giF( � deta�oi �onom morf noita�oi fo �cudorp �t�e�a k� etm� ot redro � �.1� x�p� PE fo �midoI �O�EM DNA �AIRET� .�i�o�twe fO nedro� � � fo elor � fo S �nu ruo 8 �otp� � ,y�c� ,� eb ot W�if�s d� yt�is�s �if -fus � ot naeppa y�sm�o�ar � � .sle�l � mur� �tavele yU�t� d� � clf�pa � Une� ;mc�bus l�n ot d�apmoc PE fo �m�necn� mm� a�e�yloP �.�n�ap ,y�nu�io�m tn�lu� e� �..�m de�r�ed d� arev /U 26( PE erup �el � de� stibbar .�rf m�ifna dna r�mt � � detM�oi d�f fo �nu�ar � fo tnvmpo�V� � �of d�een �m/U �,07�( � vvlfc�ib y� �itU�uq H� d�p mh ]91[ r�oG d� �n� ,� yb �ena �tsalpa Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 3 of 11 76238900 CTI-MA 006891076MA erew � � �eHmap etau� ot redro � y�nu�i e� ni se�l etaren� ot d� �e� cifshpa �tw �nkt� e� morf )� 57-5( mm�fv stnuoma suo�V PE � W�rU � P� mm� fo WilnedI l�o�ummI .�fo semu�v tnereff� e�m ro �rht ta et�ilp� � deru� et� �lpm� HA .no�f�ar� retfa � ruof n� d� erofeb ylet�mi deretem �u� � � dah sH� �lb der fo no�u�rt g�qe� �lpa �o�we ht� ne� �o d� � ,noit�da � .�p s�yl�o� a no eruaaf �ner cino� �ne� rec�c tnena lmmmir�E saw�bo� � yb r�a� morf ydobitna fo tnemec�ps � .det�en cit,noon fo t�ffe eht ,�af � nI .de�em m� �on� fo �uiov � � d�of �ubo� �m� fo tnuoma �a � ht� detiutni y�neuqesb� erew �r&� ,y�a PE e� ni W�c�orc �s a dw�snomed �o� �m� n�uh ec� .)xer � �muh d� ,)xet� � m� �uh ,eno�oh �eto�ocy� �ubo� fo yt�ifca�rc eht g�eted yb detaul�e � y�m�o�m� e� fo W�V -d� e� .)eB/B �( � del�a�u fo �n�a e� � g�b �t�fo tnecr� � d�xe at� y�onu� e� .Unemer�m � morf de�a�t�s s� k�lb s�t ;det�lpderp �lpmaS .4.7 Hp ,�a�m� �i�s et�ilpud � dey� -o�i eht rof dr�s e� sa �H� citamotua na ni detnuoc setatip�'� d�d � dna ,�t�d tnu� �,d�iftn� �ew �lp� e� ,C�4 ta noitabuc� rh� �nvit�da na �tfa ;yt�ca dnuob eht etatipderp o� �d� neht saw )m�es �-itna fo � su� mu�s enum � e� etatip�p �luf ot �O� ylsuo�e� tnuoma tibb� fo � 5 � �Hu� na( �bo� � ttbbm.� tmG .r� fo noitidda e� te�.C�4 ta sy& e� 2 rof detab� n� dna � del�k fo no�da e� ot roirp C�4 ta � 2 rof det�erp et� M 50.0 � �tulfd )z�rF-�P ,lov�ov �0( m�S tibbn er� d� )� �3-5(m� � �/U 26( �o� d� )� � I( �natS .y� � �a� �uh fo to� � � ,y�num�o�m � nI � �f detcel� � mm�ifna e� .]03[ � �iru enoruen ot yt�ba ke� r�f y�lb �om c�e�cy� ,detardyh e � �deta�e y�i� �ew d�ole�d mekt� e� .]92[ )lov/tov �05( t�vu�a ,'dnuegF etepmoc d� ,A7 � ,eta� mui� M 50.0 � d� )s�et� k� �a snoitcej� re�b 3 yb de�of �d �u� l�i� � 5�( �.e� fo �oUce� �oen� .PE det�i e� fo �2 fo 8 �nib a dedle� ya�mnu� � � �,1:1 fo �ltart�c�c I�F a ta de� m�t� � �24 fo ti�tam� a dah tibbar lounoc a �ehw ,%83 fo t�tameh a dah tibb�s� .� fo U 6 > deretuen ,)y�ib yb gar/U 26( � �n�u �hfo noitar�erp �h�V mlfeim�r�lfy�F deittup ;�lnh�T �ls ot s� PE murtnA �m�mummioii�R �b Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 4 of 11 86238900 CTI-MA 106891076MA � evah ew taht ymsaonumnh PE ehT .]72-02[ nota�itsevnifo spuorg lareves yb syassa -onummioidar PE fo tnempoleved � rof dewolla sah ]91[ ocitanidoi rof )yassaotb yb 8 m PE yraniru namuh deifirup ylhgih fo seititnauq llams fo ytilibklava �hT /U 000,07( .)4 �tV( � yrauLru detanidoi dna PE mures evitcaonommi rof semulov aoitule ralimis dedleiy aimene eitralpa htiw tneitap a morf mures fo 001-G xedabpeS no y�lpargotamorhc le8 ,noitidda nI .)3 �F( PE yraniru dna mures neewteb ytiralimis lacigolonummi gni�esgus ,PE yrsn -4tu drednsts'�o taht htiw msilellarap dewohs yamaonummi eht ni senil etareuc� ot desu )A/ htiw stneitap eht morf mures fo stnaonm mnirev ,revoeroM .)H elbaT( alsalpa diorhtyre htiw tneitap 57-5( aimena eitsalpa eht ni yllacitamard demerccd eulav PE eht ,eromrehtruf ;stneitap recnec eerht lla ni tahw -emos desaerced level PE eht ,notsufmart retfa stneitap recnac eht fo owt ylno ni desaerc -ni tlrcotameh eht hguohtlA .aisalpa diorhty�e htiw tneitap eno dna stneitap recnac cimena eerht ni detaulave saw noitartnecm�e PE mures no noisufsnart fo tceffe etuca ehT .elbairav ylhgih osla saw eruliaf laner cinozhc htiw stneitap eht ni aimena fo eerged ehT .derusaem �xev� slevel �1 mures hcihw ta emit eht saw hcihw ,�ylaid -omeh ?t �oirp yletaidemmi ld/gm 71-5 morf desnir stneitap eseht ni snoitartnecnoc eniaitaerc mures eht ,revoeroM .stcejbus lamron eht fo taht deppalrevo )lm/Um 511-81<( esnar eht ,stcejbus lamron naht )lm/Um 5.04( noitart�/ecnoc PE mures naem rehgih a dab eruliaf laner cinorhc htiw stneitap hguohtla ,dnah rehto eht nO.snoitartnecnoc PE nnne�. elbatcatednu dah stcejbus lamron ruo fo �02 ylnO .)lm/Um 81<( PE fo alevel des�,.�ced dah arev almehtycyloP htiw stneUap eerht ,ymaonummi �uo nI .)lm/Um 434,6-489 agner( lm /Um 784,3 fo eniev naem a htiw PE fo moitartneenoc mures detcele yldekram dah aimena citsalpa ereves htiw stneitap enin ,tsartnoc nI .)I elbaT( lnr/Um 92 fo eulav naem a htiw lm /Um 18 ot 81< morf degnar slaudividni lamron 91 ni PE fo nOitartnecnoc muresehT .sntlnbo18 ammag yb recart mo�f �do�tne fo tnemecalpsid cificeps-non gnidulc�h yb snoitarmecnoc PE mures etamitserevo ton did ew ,�uhT .ylevitcepser ,mures nwonknu fo 1�003 dna ,002 ,001 ni PE fo noitanimreted eht rof snilubolg ammag lm/gm 0.7 dne ,5.3 ,57.1 gniniatnoc de� erew sevruc drednats.etarapes ,ya�aonunnni eht ni milnbolg ammag hCnUh fo ytiVitcaer saw ereht ecniS .)2 �F( 000,1:1 fo nnitmtnecnoc lanif a ta mures PE-itna ebut yassa eht ni PE fo lm/Um 5 tceted ot elba saw ehT na gnisu yaasacnummioidm �TLU�ER .�f �ae � d�m o� � � � ta �nebro�A .y� �m�o� � eht � d� d� ,det� ,detceif� �ew �o�c� ret�-e� .PE �t� e� fo e�lov d� re� e� e� ot ,[s2� ,)o� �ul� e � dne ,)i� m� e� .� � nru.os M .3�.0 d� det�e dna C�4 ta a no d�tanoi�arf �o etir wolf a dna � 02 fo er�p �m�yh a ht� ,4.7 Hp ,�a ,eddo� �id� M � 1.0 .et�mhp m� M l0,0 fo no�ul� a � detar�e �w �uloc e� .�l-G xed�p� fo �ul� �28 � 3.1 � �ene c�lpa � tne� a mo� �res �o �0� �-1 A a�m�A c�ipA �W ,� � �F m� � yhp�hC l� Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 5 of 11 96238900 CTI-MA 206891076MA .yas�onummioidar yb denimreted erew PE fo snoitartnecnoc mures rieht nehw emit eht ta detaertnu erew ,noit�ltscvni tneaerp eht ni deiduts ,arev MarehtycyloP htiw stneitap llA .] 13[ )lmiUm 81<( slevel elbatcetednu dah otev aimehtycyloP ht/w deiduts stneitap eerht eht sa�ehw ,)lm/Um 92 �aem( snoitartnecnoc PE mures clbatcctelc dah. stcejbus lanwton ruo M �08 taht dnuof evah eW .secnUsmucric tsom nf PE fo snoitartnecnoc lam�on mor� desaerced etandrbrcsid ot osla tub a�nena citsalpa ni dnuo� slevel PE mures denav eht eta�itxmuq ot ylno ton yticlf�ps dna ytivitisnes tneiciffus sah troper siht ni lc�bi�cs .aJsalpa diorhty�e h�'iw tneitsPa 051 93 00�1 34 53 03 92 22 23 �p F M 82 67 36 4 3 81< tsoP 54 eiP 63 tsol M � �A t'�jbaS �! )�( tt�ot�,relt 511-8i< 81< 03 $.04 81< F 7 ,M 4 08-$:2 11 3 9 eruliaf laner cinozhC arev 434.6,489 18-81< M3 F3 F8 342.2 71 DS P.v z 784.3 92 .P .M 6 ,M xeS aimena citsalpA 36-62 63-1 2$-�2 91 .oN esnaR � na�M e�A lamroN stcejbuS .emliaP laneR cdroulC hti/V stneitaP .)�w/tw( � �- 0I X 7 ,detciped k �nI]ubol� muma� �mmuhf0 wJvJ�cam-�so�c llams ehT .yt/vitc�mo�c on dewohs nJmub]� dna �omroh gni�alum�dio�yht namuH .PE lmtUm $ � ytd�ut�n� ya�m �,,�vA .0�0,1:� fO noifa'xt�mcnoc � � ta PE-ttna s�isu PE ro't �uc dradnats ymaonumm�idthl .2 .giF Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 6 of 11 07238900 CTI-MA 306891076MA "eht sa PE erupmi gar'su daecudoxp ,PE rof ytiniffa hgih dna retit wol fo aresitna htiw depolev ..�d..eb elbaUer taht setartsnomed yamonummio�ar PE ruo ,eromrehtruF .enolc dlo�h�yrc n� yassa tnangilam a fo dellortnocnu na eb ot naeppa esaesid siht esuaceb PE mures fo seulav elbtt�etednu evah ot detcepxe neeb evah dluow arev timehtycyloP htiw stneitap ehT noitarefil�orp .kaup PE eht �t roirp Sn�tul� nimubla dna mJlubot� rof skaep nietorp swohs 082A .)22.0C � y�e�saw �Ee( PE delebil fo taht dna 42.)� saw PE eviCcaonummi fo v�ri � .yant�nummJoidm yb noitcarf hcae fo dI 05.2 qL derusaem s�v PE .det nuoo erew d�cello� � eht dna ,mures eht htiw dehpa,�otmuozidoc �w PE]I�J .8imemI c�salpa t�e�p � morf mures fo lm lfo nmuloc 00I.G .�dulpeS t no yhpm�otmnoch ,e � .4 eFiF htiw .)40.0-( -nej)o dradtrals fo tmlt es otnas eht ylLucltsitats erew )01.0- ot 40.0-( stneitap ruof eseht ni WivU�aonum PE eht yb detsre�eg �enU eht �o sepols ehT .)oC PE ycantru drtdnats fo taht ot lelIsrtp �enil detarc dna ,o ,6 ,�( �lmemI Oit�lpa htiw ttzleU�pevUatm�scrper ruof morf snoituliD .3 .�iF lp MI,IN_FS muresro 4,--( lm/Um PE 5� sedduoK dnir ,nemffoil ,biuer�Z :euql�lceT 09 Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 7 of 11 17238900 CTI-MA 406891076MA .7�91,336:971 )ndd .8791 ,668:301 e�e .6691.3�6:2&1 �na� ,921:301 � .�ik tazfo � � s yb �if� :ni�opmht� :� �roG ,F� m�C .3 .5691 ,794:� �ht� mA �u�p �po�twe � � e�p � d� � �o�ttxuj ,o �utit� �fo � :G � �M g� .,� �al�lA .B � ,BH �om� .2 .0�I � �B p� � � �od c�o � � lli �otetif elfeioporhty�E :PJ !teaN .l SECNEREFER -MA( dr�A tn�polev� �it�oF y�m� ,58132-AC ,847�AC .�n�s� deppuS oha eW .� r�r� �eR � a fo tneip�er eht si �dJru� .� .dnuF � l�oitamet� e� d� ,dnuF rekc�e� � ,�550-� s� �ow s� �SU � morf � yb �ap � �e� t�]lecxe reh rof �aW .E elo� .T .J .rD d� DM ,er� ,n� ,@�S pm� ,o� m� .� �om e� 8 �ofr� �f � ,He� �neR sal� .� �t o�a eW .� ot � Wa�u �uh �mp � I� e� fo �B � doo� e� ,� .P .�.,r�d� .E .� fo W �r� e� eta�a ylf� n�ua � STN�M�LWON�CA d�xe.ot �w �pu k�rf -ot�eh � PE fo ecnsn� c�oloi�hp � fo g�natsred� r� � deddorp � y�mio� elb�er ,e� a fo tne�oleved e� ,e�f worr� �eht fo esu�eb;PE d�n�s � ot �is ,� fo �aU detsvele y� d� �e� �if�pa erev� � stneitap eht �et�icit� � �du d�s ot �ei� c.�a�ot� 1� d� c�o�num .@i� � cit�pa � stm� ni � gn�alucr� �t ,�el�treveN g�eff� w� ylb�orp dna �t� t�eff� ta �cr� � morf dereit � ot y]e�h � o� d�w s�of � .�u� 1� � stn� ni PE �itc�m� gnitsl -�c fo y�ota� 1� yb �Z�:� d�d �t�cer� ]23[ �dl� dna ,le�E ,�e� .� � ot �d d�uder � yle� � d�ow � fo etir �t ,noif�da � .� yend� d� o� eud d�ero�.ro �na redie t�im PE fo s�S .�] � m� �r�id �v rof �a ;�c�f � iaudi� gndeff� sa llew � ,anna fo seled �otcaf �fo htob �neif� � �1 �. m� fo �r &� e� .evitca ygoloib s� y�nu�oidn yb der� � � PE �t.t� detius stnetap c�e� ot� �lb derf0 no�f�t �o � � s�el � �ifcmnum� m� ni �c dipar � .yt�iffa dna ret� r� �obfo �it� fo noi�ud� �t t� dluo� � delf �up y�M fo �ifn� rial fo yti�b�na e� �t �eve� .]52[ �G d� ,dewehS ,�aG d� ]62[ r�G d� �e� yb de�op� e� ot ra� R� snoit�n�n� � ladon r� .r�aU sa d�u h� erup taht deddorp ,�o�m� Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 8 of 11 27238900 CTI-MA 506891076MA .23 .4791 ,138:G1 .03 .92 .82 .7"2 .62 .9791 .22 .I� .02 .91 .81 .71 �I �51 .41 n�cudmp �po�e � �nmff� A :rJ F nUtS ,D �oH � �dd�S .�I .7591 � p�c� � .�=io�r�e fo �o� fo ot b�r ,342:49 de� fo �n�s� .11 .c�wyl� dna d�otc�yh d�A ,�; �o�m� �ud� :� � �D doeLcM ,A� n�hpe� .OI .9 .8 .7" .6 d� ,�ffoH �Z :euqlmdeT Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 9 of 11 37238900 CTI-MA 606891076MA .CNI ,SSIL .R NALA 1891 ,1 REBMUN ,11 EMULOV ,.YGOLOTAMEH LANRUOJ Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 10 of 11 Case 1:05-cv-12237-WGY Document 534-25 Filed 06/20/2007 Page 11 of 11 47238900 YGOLOTAMEH FO LANRUOJ NACIREMA CTI-MA 706891076MA

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